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Pflügers Archiv

, Volume 360, Issue 1, pp 1–6 | Cite as

Peritubular transport of urate in rat kidneys

  • E. C. Foulkes
Article

Summary

Measurement in the rat of renal artery-to-vein transit times permitted evaluation of movement of14C-labelled urate and of other solutes out of the peritubular inulin spaces in the renal cortex. No interaction between urate and PAH could be demonstrated at this level. Provided the peritubular disappearance may be equated to cellular uptake a mean unidirectional urate flux across peritubular membranes equal to about 1/3 of total renal load may be calculated. This value greatly exceeds the net secretory flux of urate. Such a fact can be explained by the likelihood of significant post-proximal reabsorption of secreted urate, and/or by the conclusion that peritubular urate permeability exceeds that of the luminal side. Assignment of the limiting step in urate secretion to the luminal cell membranes, in contrast to a determining role played by peritubular membranes in PAH transport, can account for the lack of interaction between PAH and urate at the peritubular membrane in rats.

Key words

Peritubular Membrane Luminal Membrane Urate Permeability Urate Secretion Rat Kidney PAH 

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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • E. C. Foulkes
    • 1
    • 2
  1. 1.Physiologisches Institut der Universität InnsbruckAustria
  2. 2.Department of Environmental Health Kettering LaboratoryUniversity of Cincinnati College of MedicineCincinnatiUSA

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