Pflügers Archiv

, Volume 392, Issue 3, pp 235–238 | Cite as

Blood flow in different adipose tissue depots during prolonged exercise in dogs

  • Jens Bülow
  • Erik Tøndevold
Heart, Circulation, Respiration and Blood; Environmental and Exercise Physiology


Adipose tissue blood flow was measured by the microsphere technique in all major adipose tissue depots in dogs during exercise. The measurements were done during rest, after 1 and 2 h of exercise and after a postexercise rest period. It was found that the blood flow to the inguinal, subcutaneous adipose tissue increased from about 6 ml/(100g·min) during rest to about 10 ml/(100 g·min) during exercise. This increase in flow was significantly smaller than the increase found in the perirenal, the mesenteric and the pericardial depots. In these depots the resting blood flow was about 10 ml/(100 g·min) increasing to about 30 ml/(100 g·min) during exercise. It is concluded that the increase in adipose tissue blood flow during exercise is a general phenomenon for all major adipose tissue depots. The increase in flow in the inguinal, subcutaneous fat pad was comparable to the previously described increase in flow in abdominal, subcutaneous tissue in man. Blood flow to abdominal skin was constant during exercise, while the flow in tissues from the gastrointestinal canal and in the kidneys decreased. The flow in the tongue and in the Achilles tendon significantly increased during exercise.

Key words

Adipose tissue blood flow Dog Exercise Kidney Microspheres Pancreas Radioactive Regional blood flow Skin Small intestine Tendon Tongue 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Armitage P (1974) in Statistical Methods in Medical Research. Blackwell Scientific Publications, Oxford, p 217Google Scholar
  2. 2.
    Ballard K, Rosell S (1969) The unresponsiveness of lipid metabolism in canine mesenteric adipose tissue to biogenic amines and to sympathetic nerve stimulation. Acta Physiol Scand 77:442–448Google Scholar
  3. 3.
    Bergmayer HV, Bernt E (1970) Bestimmung mit Glucose-Oxydase und Peroxydase. In Bergmayer HV (ed) Methoden der enzymatischen Analyse. Verlag Chemie, Weinheim, p 1172Google Scholar
  4. 4.
    Buckberg GD, Luck JC, Payne DB, Hoffman JIE, Archie JP, Fixler DE (1971) Some sources of error in measuring regional blood flow with radioactive microspheres. J Appl Physiol 31:598–604Google Scholar
  5. 5.
    Bülow J, Madsen J (1976) Adipose tissue blood flow during prolonged, heavy exercise. Pflügers Arch 363:231–234Google Scholar
  6. 6.
    Bülow J, Hansen M, Madsen J (1976) Variation in human subcutaneous adipose tissue blood flow (ATBF). Acta Physiol Scand 96:30A-31AGoogle Scholar
  7. 7.
    Bülow J, Madsen J (1978) Human adipose tissue blood flow during prolonged exercise II. Pflügers Arch 376:41–45Google Scholar
  8. 8.
    Bülow J (1981) Human adipose tissue blood flow during prolonged exercise III: Effects of β-adrenergic blockade nicotinic acid, and glucose infusion. Scand J Clin Lab Invest 41:415–424Google Scholar
  9. 9.
    Bülow J, Madsen J (1981) Influence of blood flow on fatty acid mobilization from lipolytically active adipose tissue. Pflügers Arch 390:169–174Google Scholar
  10. 10.
    Fan F-C, Schuessler GB, Chen RYZ, Chien S (1979) Determinations of blood flow and shunting of 9- and 15 μm spheres in regional beds. Am J Physiol 237:H25-H33Google Scholar
  11. 11.
    Hales JRS (1974) Radioactive microsphere techniques for studies of the circulation. Clin Exp Pharmacol Physiol (Suppl 1):31–46Google Scholar
  12. 12.
    Hales JRS, Dampney RAL (1975) The redistribution of cardiac output in the dog during heat stress. J Therm Biol 1:29–34Google Scholar
  13. 13.
    Hohorst HJ (1970) Bestimmung mit Lactat-Dehydrogenase und NAD. In Bergmayer HV (ed) Methoden der enzymatischen Analyse. Verlag Chemie, Weinheim, p 1422Google Scholar
  14. 14.
    Laurell SL, Tibbling G (1966) An enzymatic fluorometric micro-method for the determination of glycerol Clin Chim Acta 13:317–322Google Scholar
  15. 15.
    Laurell S, Tibbling G (1967) Colorimetric micro-determination of free fatty acids in plasma. Clin Chim Acta 15:57–62Google Scholar
  16. 16.
    Sanders TM, Werner RA, Bloor CM (1976) Visceral blood distribution during exercise to exhaustion in conscious dogs. J Appl Physiol 40:927–931Google Scholar
  17. 17.
    Shaw WAS, Issekutz TB, Issekutz BJr (1975) Interrelationship of FFA and glycerol turnovers in resting and exercising dogs. J Appl Physiol 39:30–36Google Scholar
  18. 18.
    Van Citters RL, Franklin DL (1969) Cardiovascular performance of Alaska sled dogs during exercise. Circ Res 24:33–42Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Jens Bülow
    • 1
  • Erik Tøndevold
    • 2
  1. 1.Institute of Medical PhysiologyUniversity of Copenhagen, Panum InstituteCopenhagen NDenmark
  2. 2.Department of Orthopedic SurgeryHillerød HospitalHillerødDenmark

Personalised recommendations