Pflügers Archiv

, Volume 377, Issue 3, pp 217–224 | Cite as

Transport and accumulation of α-aminoisobutyric acid (A.I.B.) in the guinea pig placenta

  • J. P. van Dijk
  • B. K. van Kreel
Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands


Active transport of A.I.B. from mother to fetus was studied. This was done in the intact animal and using the isolated placenta, artificially perfused at both sides. It was shown that A.I.B. is actively accumulated in the placental cells. An estimate of the kinetic constants is given. It is shown that this accumulation takes place predominantly from the maternal side of the placenta.

A.I.B. that has been accumulated is cleared to the maternal and fetal circulation in equal amounts. So the netto active transport from mother to fetus is brought about by an unequal distribution of carriers, the maternal side being most active.

Key words

A.I.B. Amino acids Active transport Accumulation Guinea pig Placenta 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • J. P. van Dijk
    • 1
  • B. K. van Kreel
    • 1
  1. 1.Department of Chemical Pathology, Faculty of MedicineErasmus UniversityRotterdamThe Netherlands

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