Pflügers Archiv

, Volume 377, Issue 3, pp 201–207 | Cite as

On the nature of the neural abnormality in human amblyopia; neural aberrations and neural sensitivity loss

  • R. F. Hess
  • F. W. Campbell
  • T. Greenhalgh
Excitable Tissues and Central Nervous Physiology


In this investigation contrast threshold measurements are compared with supra-threshold perception for a group of human amblyopes. The results indicate that human amblyopia involves, in some cases, not only loss of sensitivity but spatial distortion. Thus a new group of amblyopes can now be identified in which only distortion occurs. These results have important physiological implications for both the normal and abnormal visual systems. Neurophysiologists investigating visual loss from deprivation should assess whether similar distortions occur in animals. This question may hold the answer to whether the present animal models are relevant to the human condition.

Key words

Contrast sensitivity Spatial distortion Neural dysfunction Amblyopia 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • R. F. Hess
    • 1
  • F. W. Campbell
    • 1
  • T. Greenhalgh
    • 1
  1. 1.Physiological LaboratoryCambridgeUK

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