Abstract
The purpose of this study was to investigate the effects of methandrostenelone (Dianabol) on contractile and performance variables in the rat. Thirty-six male Sprague Dawley rats 90 days old were divided into sedentary and exercise groups; they were further subdivided into Dianabol (0.35 mg/kg/day) treated and untreated groups. The exercise groups underwent a program of high intensity training 7 days/week for 6 weeks. Training produced changes in isometric force-time characteristics indicating increased production of tension. Performance test scores increased significantly from 3 weeks to 6 weeks. Performance by exercise and exercise with Dianabol groups was indistinguishable. It is concluded that Dianabol did not significantly alter the adaptations of the rat to high intensity training.
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Bagby, G., Sembrowich, W., Gollnick, P.: Myosin ATPase and fiber composition from trained and untrained rat skeletal muscle. Am. J. Physiol.223, 1415–1417 (1972)
Baldwin, K. M., Martiner, O. M., Cheadle, W. G.: Enzymatic changes in hypertrophied fast-twitch skeletal muscle. Pflügers Arch.364, 229–234 (1976)
Brown, J., Tait, G.: Anabolic steroids—the views of the users. Track Tech.54, 1713–1716 (1973)
Burke, R., Edgerton, V. R.: Motor unit properties and selective involvement in movement. In Exercise and sport sciences reviews, Vol. 3 (J. Wilmore and J. Keough, eds.), pp. 31–81. New York: Academic Press 1975
Easton, D.: Nerve-end recording in conducting volume. Science132, 1312–1313 (1960)
Edgerton, V. R.: Neuromuscular adaptation to power and endurance work. Can. J. Appl. Sport Sci.1, 49–58 (1976)
Exner, G., Staudte, H., Pette, D.: Isometric training of rats—effects upon fast and slow muscle and modification by an anabolic hormone (Nandrolone Decanoate). I. Female rats. Pflügers Arch.345, 1–14 (1973)
Exner, G., Staudte, H., Pette, D.: Isometric training of rats—effect upon fast and slow muscle and modification by an anabolic hormone (Nandrolone Decanoate). II. Male rats. Pflügers Arch.345, 15–22 (1973)
Freed, L., Banks, A., Longson, D., Burley, D.: Anabolic steroids in athletics: crossover double-blind trial on weightlifters. Br. Med. J.2, 471–473 (1975)
Hicks, C. R.: Fundamental concepts in the design of experiments. (2nd Ed.). New York: Holt, Rinehart and Winston 1973
Hickson, R., Heusner, W., VanHass, W., Taylor, J., Carron, R.: Effects of an anabolic steroid and sprint training on selected histochemical and morphological observations in rat skeletal muscle types. Eur. J. Appl. Physiol.35, 251–259 (1976)
Johnson, L., O'Shea, J.: Anabolic steroid: Effects on strength development. Science146, 957–959 (1969)
Johnson, L., Fisher, G., Silvester, L. J., Hofheins, C. C.: Anabolic steroid: Effects on strength, body weight, oxygen uptake and spermatogenesis upon mature males. Med. Sci. Sport4, 43–46 (1972)
Lamb, D.: Androgens and exercise. Med. Sci. Sport7, 1–5 (1975)
O'Shea, J., Winkler, W.: Biochemical and physical effects of an anabolic steroid in competitive swimmers and weightlifters. Nutr. Rep. Int.2, 351–362 (1970)
Ryan, A. J.: Guarded approval of steroids. The Physic. Sports. Med., Dec. 13 (1976)
Staudte, H., Exner, G., Pette, D.: Effects of short-term high intensity (sprint) training on some contractile and metabolic characteristics of fast and slow muscle of the rat. Pflügers Arch.334, 159–168 (1973)
Stone, M. H.: The interrelationship of gonadotropins and synthetic anabolic steroids during exercise and their effect of skeletal muscle. Unpublished Ph. D. dissertation. The Florida State University (1977)
Ward, P.: The effect of an anabolic steroid on strength and lean body mass. Med. Sci. Sports5, 277–282 (1973)
Winmay, M., Mya-Tu, M.: The effect of anabolic steroids on physical fitness. J. Sports Med.15, 266–271 (1975)
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Stone, M.H., Lipner, H. Responses to intensive training and methandrostenelone administration I. Contractile and performance variables. Pflugers Arch. 375, 141–146 (1978). https://doi.org/10.1007/BF00584236
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DOI: https://doi.org/10.1007/BF00584236