Abstract
Smooth muscles actively accumulate Cl. Abolition of the transmembrane Na gradient has been shown to lead to a passive distribution of Cl. This suggested to us that Na and Cl may move together across the smooth muscle cell membrane, Cl accumulation resulting due to [Na]i being less than [Na]o. In favour of this view are the findings that Cl uptake is reduced in Na-free medium, Na uptake is reduced in Cl-free medium, reducing [Cl]i reduces Na efflux, and increasing [Na]i increases Cl efflux.
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Widdicombe, J.H., Brading, A.F. A possible role of linked Na and Cl movement in active Cl uptake in smooth muscle. Pflügers Arch. 386, 35–37 (1980). https://doi.org/10.1007/BF00584184
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DOI: https://doi.org/10.1007/BF00584184