Pharmacological zero for electromagnetic renal blood flow measurement
- 14 Downloads
Measurement of blood flow in chronically instrumented laboratory animals using electromagnetic flow probes depends on a reference “zero flow” value. The latter is usually obtained by mechanical vessel occlusion. We tested an alternative method: a bolus of angiotensin II was injected in the abdominal aorta resulting in an immediate decrease of renal blood flow. Diastolic blood flow at this stage appeared to be identical to the zero level obtained by mechanical occlusion. Thus, pharmacological interruption of renal blood flow may serve as a zero reference in the dog.
Key wordsElectromagnetic blood flow measurement Renal blood flow Angiotensin II Vessel occluder
- DiSalvo J, Fell C (1970) Effects of angiotensin on canine renal blood flow. Proc Soc Exp Biol Med 133:1432–1434Google Scholar
- Thurau K (1971) Niere. In: Bauereisen E (ed) Lehrbuch der Physiologie. Physiologie des Kreislaufs 1. Springer, Berlin Heidelberg New York, p 321Google Scholar
- Zimmerman BG, Mommsen C, Kraft E (1980) Sympathetic and renin-angiotensin system influence on blood pressure and renal blood flow of two-kidney, one-clip Goldblatt hypertensive dog. Hypertension 2:53–62Google Scholar
- Zweens J, Schiphof P (1976) Permanent catheterization of aorta and pulmonary artery in the dog. Pflügers Arch 362:201–202Google Scholar