Abstract
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1.
Successive cumulative concentration-response curves for the contractile action of norepinephrine (NE) were constructed for isolated aortic strips prepared from untreated and reserpinized rabbits.
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2.
Aortas of reserpinized rabbits were initially more sensitive to NE; i.e., lower EC50 and greater capacity of contraction. Successive applications of NE to the aortas (i.e., “sensitization” of the aortas) of untreated rabbits produced a decrease in EC50 and an increase in the capacity of contraction, whereas such a development of the response to NE was not evident with aortas of reserpinized rabbits.
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3.
To make valid comparisons among agonists of NE-receptors using aortic strips, it seems necessary to subject these preparations to an identical degree of sensitization.
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Auguet, M., DeFeudis, F.V. & Clostre, F. Differences in the development of sensitization to norepinephrine between isolated aortas of untreated and reserpinized rabbits. Pflugers Arch. 393, 275–277 (1982). https://doi.org/10.1007/BF00584082
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DOI: https://doi.org/10.1007/BF00584082