Pflügers Archiv

, Volume 393, Issue 3, pp 227–231 | Cite as

Renal handling of homologous and heterologous insulin in the isolated perfused rat kidney

  • Eberhard Schlatter
  • Hans-Joachim Schurek
  • Reinhard Zick
Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands


  1. 1.

    Renal handling of pig-and rat-insulin was studied in the isolated perfused rat kidney.

  2. 2.

    Metabolic clearance rates of both pig- and rat-insulin excceded GFR.

  3. 3.

    Peritubular uptake of pig-insulin accounted for 13%, of rat-insulin for 31% of the total metabolic clearance.

  4. 4.

    The nonfiltering kidney does not remove insulin from the peritubular circulation.

  5. 5.

    Metabolic clearance rates of pig- and rat-insulin are directly related to GFR.

  6. 6.

    The filtration process seems to be necessary for the uptake of insulin at the peritubular site.


Key words

Isolated perfused rat kidney Insulin Metabolic clearance rate Radioimmunoassay Filtering nonfiltering kidney 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Eberhard Schlatter
    • 1
  • Hans-Joachim Schurek
    • 1
  • Reinhard Zick
    • 1
  1. 1.Zentrum Innere Medizin and Zentrum PhysiologieMedizinische Hochschule HannoverHannoverFederal Republic of Germany

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