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Pflügers Archiv

, Volume 356, Issue 3, pp 267–275 | Cite as

The transport ofd-glucose,l-glucose andd-mannose across the isolated guinea pig placenta

  • H. Schröder
  • H. -P. Leichtweiß
  • W. Madee
Article

Summary

Studies were carried out on the transport of3H-d-glucose,14C-l-glucose and3H-d-mannose across the isolated artificially perfused guinea pig placenta and the inhibition of these transports by phloretin was investigated.
  1. 1.

    In 10 out of 13 placentas the transfer ofd-glucose exceeds that ofl-glucose.

     
  2. 2.

    In 10 out of 13 placentas the transfer ofd-mannose exceeds that ofl-glucose.

     
  3. 3.

    Phloretin (1×10−3 M/l) decreases the transport ofd-glucose, and ofd-mannose, it does not decrease the transport ofl-glucose. The inhibition is not complete.

     

The characterization of the washing-out curves permits the assumption that some placentas (6 out of 21) cannot discriminate betweend- andl-hexoses, because a non specific transfer (simple diffusion) covers the specific one.

Key words

Placental Transport d-Glucose d-Mannose l-Glucose Phloretin Washing-Out Curves 

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References

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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • H. Schröder
    • 1
  • H. -P. Leichtweiß
    • 1
  • W. Madee
    • 1
  1. 1.Abteilung für experimentelle Medizin der Universitäts-Frauenklinik und-Poliklinik HamburgGermany

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