Pflügers Archiv

, Volume 356, Issue 3, pp 193–208 | Cite as

Simultaneous perfusion of both coronary arteries and drainage of the coronary sinus in the dog heartin situ

  • J. R. Brunsting
  • K. R. Visser
  • W. G. Zijlstra
Article
  • 26 Downloads

Summary

A technique is described for perfusion of the entire coronary arterial system of the dog heartin situ and for drainage of the coronary sinus blood. Both coronary arteries are cannulated without ligation of major ventricular branches and disconnected from the aorta. The cannulas are connected to an extracorporeal system allowing perfusion under controlled pressure, without ill effects to either the heart or the blood. The arterial perfusion system is fed from the femoral arteries of the dog. The coronary sinus is cannulated for draining the blood to a venous reservoir against a controlled pressure. From the reservoir the blood is pumped into a femoral vein. Thus a preparation is obtained in which the interdependency of coronary circulation and performance of the heart has been discontinued. Under careful monitoring of pressures and flows, and of blood temperature, blood gases and plasma electrolytes, the preparation has been kept in excellent condition for up to 7 hrs.

Key words

Open Chest Dog Heart Perfusion Technique Extracorporeal Circulation Coronary Arteries Coronary Sinus 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Anrep, G. V., Blalock, A., Hammouda, M.: The distribution of the blood in the coronary blood vessels. J. Physiol. (Lond.)67, 87–96 (1929)Google Scholar
  2. 2.
    Arnold, G., Morgenstern, C., Lochner, W.: The autoregulation of the heart work by the coronary perfusion pressure. Pflügers Arch.321, 34–55 (1970)Google Scholar
  3. 3.
    Arnulf, G., Martin, Cl.: Fibrillation ventriculaire au cours du rétablissement circulaire dans les artères coronaires (Fibrillation de déclampage). Arch. Mal. Cœur66, 869–876 (1973)Google Scholar
  4. 4.
    Blair, E.: Anatomy of the ventricular coronary arteries in the dog. Circulat. Res.9, 333–341 (1961)Google Scholar
  5. 5.
    Cooley, A. D., Reul, G. J., Wukasch, D. C.: Ischemic contracture of the heart: “Stone heart”. Amer. J. Cardiol.29, 575–577 (1972)Google Scholar
  6. 6.
    Gregg, D. E.: The coronary circulation in health and disease. London: Kimpton 1950Google Scholar
  7. 7.
    Gregg, D. E., Pritchard, W. H., Shipley, R. E., Wearn, J. T.: Augmentation of blood flow in the coronary arteries with elevation of right ventricular pressure. Amer. J. Physiol.139, 726–732 (1943)Google Scholar
  8. 8.
    Han, J.: Ventricular vulnerability during acute coronary occlusion. Amer. J. Cardiol.24, 857–864 (1969)Google Scholar
  9. 9.
    Hirsch, E. F.: The innervation of the vertebrate heart. Springfield, Ill.: Ch. C. Thomas 1970Google Scholar
  10. 10.
    Katz, L. N., Jochim, K., Bohning, A.: The effect of the extravascular support of the ventricles on the flow in the coronary vessels. Amer. J. Physiol.122, 236–251 (1938)Google Scholar
  11. 11.
    Kenaan, G., Mori, T., Kay, J. H.: Elongation and exteriorization of the coronary sinus: surgical technique in laboratory animals. J. thorac. cardiovasc. Surg.65, 155–158 (1973)Google Scholar
  12. 12.
    Moir, T. W., Eckstein, R. W., Driscol, T. E.: Thebesian drainage of the septal artery. Circulat. Res.12, 212–219 (1963)Google Scholar
  13. 13.
    Morawitz, P., Zahn, A.: Untersuchungen über den Coronarkreislauf. Dtsch. Arch. klin. Med.116, 364–408 (1914)Google Scholar
  14. 14.
    Osborn, J. J., Swank, R. L., Hill, J. D., Aguilar, M. J., Gerbode, F.: Clinical use of a Dacron wool filter during perfusion for open-heart surgery. J. thorac. cardiovasc. Surg.60, 575–581 (1970)Google Scholar
  15. 15.
    Rayford, C. R., Khouri, E. M., Lewis, F. B., Gregg, D. E.: Evaluation of use of left coronary artery inflow and O2 content of coronary sinus blood as a measure of left ventricular metabolism. J. appl. Physiol.14, 817–822 (1959)Google Scholar
  16. 16.
    Rispens, P., Brunsting, J. R., Zijlstra, W. G., van Kampen, E. J.: Determination of total carbon dioxide content in blood and plasma by means of the cediometer. Theory and experimental verification. Clin. chim. Acta22, 261–271 (1968)Google Scholar
  17. 17.
    Rispens, P., Brunsting, J. R., Zock, J. P., Zijlstra, W. G.: A modified Singer-Hastings nomogram. J. appl. Physiol.34, 377–382 (1973)Google Scholar
  18. 18.
    Rogers, R. M., Spear, J. F., Moore, E. N., Horowitz, L. H., Sonne, J. E.: Vulnerability of canine ventricle to fibrillation during hypoxia and respiratory acidosis. Chest63, 986–994 (1973)Google Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • J. R. Brunsting
    • 1
  • K. R. Visser
    • 1
  • W. G. Zijlstra
    • 1
  1. 1.Laboratory of Chemical PhysiologyUniversity of GroningenThe Netherlands

Personalised recommendations