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Hormones and the stimulated sodium transport in cecum hypertrophy

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Summary

Sodium transport per unit tissue is stimulated in dietetically produced cecum hypertrophy of the rat. Presumably this reflects an adaptive process. The possibility was tested whether transport adaptation was mediated by hormones, particularly by the pituitary-adrenal system. Cecum hypertrophy was induced by dissolving polyethylene glycol in the drinking water, and cecal sodium and water net absorption was measuredin vivo. In both the adaptedand normal mucosa, sodium and water absorption per unit macrosurface or dry weight was increased by aldosterone and decreased by adrenalectomy, hypophysectomy and volume expansion while the decrease following adrenalectomy was reversed by cortisol and the absence of antidiuretic hormone in hereditary diabetes insipidus rats had little effect on absorption. However, none of the test conditions abolished the relatively larger absorption of the adapted compared to the normal mucosa. It is concluded that the hormonal effects were additive but not causally related to transport adaptation.

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References

  1. Aulsebrook, K. A.: Effect of vasopressin on sodium transfer by rat colon in vitro. Endocrinology68, 1063–1065 (1961)

    Google Scholar 

  2. Cofré, G., Crabbé, J.: Active sodium transport by the colon of Bufo marinus: stimulation by aldosterone and antidiuretic hormone. J. Physiol. (Lond.)188, 177–190 (1967)

    Google Scholar 

  3. Dowling, R. H., Riecken, E. O., Laws, J. W., Booth, C. C.: The intestinal response to high bulk feeding in the rat. Clin. Sci.32, 1–9 (1967)

    Google Scholar 

  4. Edmonds, C. J., Marriott, J. C.: The effect of aldosterone and adrenalectomy on the electrical potential difference of rat colon and on the transport of sodium, potassium, chloride and bicarbonate. J. Endocr.39, 517–531 (1967)

    Google Scholar 

  5. Edmonds, C. J., Marriott, J.: Factors influencing the electrical potential across the mucosa of rat colon. J. Physiol. (Lond.)194, 457–478 (1968)

    Google Scholar 

  6. Edmonds, C. J., Marriott, J.: Sodium transport and short-circuit current in rat colon in vivo and the effect of aldosterone. J. Physiol. (Lond.)210, 1021–1039 (1970)

    Google Scholar 

  7. Edmonds, C. J., Thompson, B. D., Marriott, J.: Interrelationship of the effects of aldosterone and thyroid hormones on sodium transport and electrical properties of rat colon. J. Endocr.48, 189–197 (1970)

    Google Scholar 

  8. Gustafsson, B. E., Maunsbach, A. B.: Ultrastructure of the enlarged cecum in germfree rats. Z. Zellforsch.120, 555–578 (1971)

    Google Scholar 

  9. Habermann, J., Henner, J., Horn, K., zur Horst, I., Scriba, P. C.: Automatization of serum thyroxine determination and of T3-uptake test. (Abstr.) Acta endocr. (Kbh.)159, 7 (1972)

    Google Scholar 

  10. Higgins, J. T., Jr., Blair, N. P.: Intestinal transport of water and electrolytes during extracellular volume expansion in dogs. J. clin. Invest.50, 2569–2579 (1971)

    Google Scholar 

  11. Holmes, W. N.: Regulation of electrolyte blance in marine birds with special reference to the role of the pituitary-adrenal axis in the duck (Anas platyrhynchos). Fed. Proc.31, 1587–1598 (1972)

    Google Scholar 

  12. Hornych, A., Meyer, P., Milliez, P.: Angiotensin, vasopressin and cyclic AMP: effects on sodium and water fluxes in rat colon. Amer. J. Physiol.224, 1223–1229 (1973)

    Google Scholar 

  13. Lee, H. W.-T., Moinuddin, J. F.: Effects of oral chlortetracycline on diarrhea and on the dry weights of cleaned intestinal organs in rats fed two different diets. Amer. J. Physiol.192, 421–426 (1958)

    Google Scholar 

  14. Levin, R. J.: Techniques, terminology and parameters in intestinal absorption. Brit. med. Bull.23, 209–212 (1967)

    Google Scholar 

  15. Levin, R. J.: The effects of hormones on the absorptive, metabolic and digestive functions of the small intestine. J. Endocr.45, 315–348 (1969)

    Google Scholar 

  16. Levin, R. J., Smyth, D. H.: The effect of the thyroid gland on intestinal absorption of hexoses. J. Physiol (Lond.)169, 755–769 (1963)

    Google Scholar 

  17. Loeschke, K., Uhlich, E., Halbach, R.: Cecal enlargement combined with sodium transport stimulation in rats fed polyethylene glycol. Proc. Soc. exp. Biol. (N. Y.)142, 96–102 (1973)

    Google Scholar 

  18. Loeschke, K., Uhlich, E., Kinne, R.: Stimulation of sodium transport and Na+−K+-ATPase activity in the hypertrophying, rat cecum. Pflügers Arch.346, 233–249 (1974)

    Google Scholar 

  19. Maetz, J.: Mechanisms of salt and water transfer across membranes in teleosts in relation to the aquatic environment. Mem Soc. Endocr.18, 3–29 (1970)

    Google Scholar 

  20. Moinuddin, J. F., Lee H. W.-T.: Possible associations of dietary residues with growth of the large gut. Amer. J. Physiol.197 903–911 (1959)

    Google Scholar 

  21. Müller, O. A., Pister, W., Schwandt P., Scriba, P. C., Weisweiler, P.: Biological ACTH-activity of lipid mobilising peptide fractions from hog pituitaries. Horm. Metab. Res.5, 258–261 (1973)

    Google Scholar 

  22. Reiter, R. J.: The endocrines and compensatory renal enlargement. In: Compensatory renal hypertrophy, pp. 183–202. Eds. W. W. Nowinsky and R. J. Goss. New York-London: Academic Press 1969

    Google Scholar 

  23. Richet, G., Hornych, A.: The effect of an expansion of extracellular fluids on net Na flux in the jejunum of rats. Nephron6, 365–378 (1969)

    Google Scholar 

  24. Schapiro, H., Wruble, L. D., Britt, L. G.: The effect of hypophysectomy on the gastrointestinal tract. A review of the literature. Amer. J. dig. Dis.15, 1019–1030 (1970)

    Google Scholar 

  25. Schrier, R. W., de Wardener, H. E.: Tubular reabsorption of sodium ion: influence of factors other than aldosterone and glomerular filtration rate. New Engl. J. Med.285, 1231–1243, 1292–1303 (1971)

    Google Scholar 

  26. Tilson, M. D., Philipps, S., Wright, H. K.: An effect of deoxycorticosterone upon the ileum simulating compensatory hypertrophy of the gut. Surgery69, 730–735 (1971)

    Google Scholar 

  27. Touloukian, R. J., Spencer, R. P.: Ileal blood flow preceding compensatory intestinal hypertrophy. Ann. Surg.175, 320–325 (1972)

    Google Scholar 

  28. Wall, A. J., Middleton, W. R. J., Pearse, A. G. E., Booth, C. C.: Intestinal mucosal hyperplasia, following induced hyperthyroidism in the rat. Virchows Arch., Abt. B Zellpath.6, 79–87 (1970)

    Google Scholar 

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Authors and Affiliations

  1. II. Medizinische Klinik der Universität, Ziemssenstraße 1, D-8000, München 2, Germany

    K. Loeschke & O. A. Müller

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  1. K. Loeschke
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  2. O. A. Müller
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Additional information

Supported by Deutsche Forschungsgemeinschaft Grant, Lo 114/5 and SFB 51. Preliminary aspects of this study have been reported (Pflügers Arch.332, Suppl. R 22, 1972).

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Loeschke, K., Müller, O.A. Hormones and the stimulated sodium transport in cecum hypertrophy. Pflugers Arch. 355, 273–280 (1975). https://doi.org/10.1007/BF00583690

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  • DOI: https://doi.org/10.1007/BF00583690

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