Summary
Amphotericin B treatment increases the thiourea,d-xylose and mannitol fluxes and lowers those of urea, N-methyl-urea, acetamide, formamide, and N-N′-dimethyl-thiourea. The degree of flux inhibition is related to the cellular permeability of these compounds.
Most probably Amphotericin B increases the permeability of all those molecules across the luminal plasma membrane, but simultaneously elicits a cellular swelling, which reduces the diffusion across the lateral plasma membranes. This effect masks the polyene effect especially for molecules showing a mainly cellular permeation pathway such as amides and lipid, soluble molecules.
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References
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Curci, S., Casavola, V. & Lippe, C. Permeability pathways for non-electrolytes through bufo bufo gall-bladder. Pflugers Arch. 355, 267–271 (1975). https://doi.org/10.1007/BF00583689
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DOI: https://doi.org/10.1007/BF00583689