Summary
Cardiovascular functions were evaluated beat by beat during 29 spontaneous deep breaths in three conscious dogs. When pleural pressure was significantly lower than during quiet breathing, stroke volume was reduced, heart rate elevated, as well as transmural pressure in the pulmonary artery\(\left( {\bar P_{PA} - P_{pl} } \right)\) and in the thoracic aorta\(\left( {\bar P_{AO} - P_{pl} } \right)\); the left ventricular filling pressure (LVEDP—P pl ) did not decrease. The authors suggest that these findings are not consistent with the classical hypothesis which explains the decrease in left ventricular output primarily by a reduction in the venous return to the left heart. The results indicate that the decrease in pleural pressure is responsible for an increase in the afterload on the left heart and suggest that this is the predominant factor in the reduction of the stroke volume without decrease in left ventricular filling pressure.
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Anrep, G. V., Pascual, W., Rossler, R.: Respiratory variations of the heart rate. Proc. roy. Soc. B119, 191–232 (1936)
Best, C. H., Taylor, N. B.: The physiological basis of medical practice, 8th ed. Baltimore: Williams and Wilkins 1966
Brecher, G. A.: Venous Return. Grune & Stratton 1956
Bugge-Asperheim, B., Kiil, F.: Cardiac response to increased aortic pressure. Scand. J. clin. Lab. Invest.24, 345–360 (1969)
Charlier, A. A.: Beat to beat hemodynamic effects of lung inflation and normal respiration in anesthetized and conscious dogs. Brussels; Arscia 1967
Coleridge, J. C., Linden, R. J.: The variations with respiration in effective right and left atrial pressure in the dog. J. Physiol. (Lond.)145, 482–493 (1959)
Ehrlich, W., Schrijen, F., Krausman, D., Caldini, P., Brady, J. V.: The effect of β-blockade on coronary and systemic circulation in dogs at rest and during exercise. Arch. int. Pharmacodyn.204, 213–227 (1973)
Ehrlich, W., Tosheff, J., Caldini, P., Abbey, H., Brady, J. V.: Adaptation of cardiac output, coronary flow, and other circulatory functions in dogs to exercise and to eating. Johns Hopkins med. J.130, 216–234 (1972)
Ehrlich, W., Tosheff, J., Caldini, P., Brady, J. V.: Adaptation of cardiac output, coronary flow and other circulatory functions in dogs to drinking. Arch. int. Physiol. Biochim.80, 521–531 (1972)
Franklin, D. L., Van Citters, R. L., Rushmer, R. F.: Balance between right and left ventricular output. Circilat. Res.10, 17–26 (1962)
Goldblatt, A., Harrison, D., Glick, G.: Studies on cardiac dimensions in intact, unanesthetized man. II. Effects of respiration. Circulat. Res.13, 455–460 (1963)
Guyton, A. C., Lindsey, A. W., Abernathy, B., Richardson, T.: Venous return at various right atrial pressures and the normal venous return curve. Amer. J. Physiol.189, 609–615 (1957)
Hamilton, W. F., Woodbury, R. A., Vogt, E.: Differential pressures in the lesser circulation of the unanesthetized dog. Amer. J. Physiol.125, 130–141 (1939)
Hoffman, J. E., Guz, A., Charlier, A. A., Wilcken, D. E.: Stroke volume in conscious dogs; effect of respiration, posture and vascular occlusion. J. appl. Physiol.20, 865–877 (1965)
Holt, J. P.: The collapse factor in the measurement of venous pressure. Amer. J. Physiol.134, 292–299 (1941)
Howell, J. B. L., Permutt, S., Proctor, D. F., Riley, R. L.: Effect of inflation of the lung on different parts of pulmonary vascular bed. J. appl. Physiol.16, 71–76 (1961)
Lauson, H. D., Bloomfield, R. A., Cournand, A.: The influence of the respiration on the circulation in man. Amer. J. Med.1, 315–336 (1946)
Ludwig, C.: Beiträge zur Kentnis des Einflusses der Respirationsbewegungen auf den Blutlauf im Aortensysteme. Arch. Anat. Physiol. Wiss. Med.6, 242–302 (1847)
Menkes, H., Forster, J., Griffith, L., Summer, W., Permutt, S.: Afterloading the left ventricle by lowering intrathoracic pressure. Am. Heart Assoc. 46th session, November 1973
Morgan, B. C., Abel, F. L., Mullins, G. L., Guntheroth, W. G.: Flow patterns in cavae, pulmonary artery, pulmonary vein, and aorta in intact dogs. Amer. J. Physiol.210, 903–909 (1966)
Morkin, E., Collins, J. A., Goldman, H. S., Fishman, A. P.: Pattern of blood flow in the pulmonary veins of the dog. J. appl. Physiol.20, 1118–1128 (1965)
Opdyke, D. F., Brecher, G. A.: Effect of normal and abnormal changes of intrathoracic pressure on effective right and left atrial pressures. Amer. J. Physiol.160, 556–566 (1950)
Permutt, S.: Relation between pulmonary arterial pressure and pleural pressure during the acute asthmatic attack. Chest63, 25–27 (1973)
Ross, J., Jr., Sobel, B. E.: Regulation of cardiac contraction. Ann. Rev. Physiol.34, 47–90 (1972)
Shuler, R. H., Ensor, C., Gunning, R. E., Moss, W. G., Johnson, V.: The differential effects of respiration on the left and right ventricles. Amer. J. Physiol.137, 620–627 (1942)
Sonnenblick, E. H., Downing, S. E.: Afterload as a primary determinant of ventricular performance. Amer. J. Physiol.204, 604–610 (1963)
Tosev, J., Daley, L. A., Hilton, A.: A method for recording intrapleural pressure in conscious, semi-restrained mammals. J. appl. Physiol.27, 902–903 (1969)
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Preliminary results were reported at the FASEB Meeting in Atlantic city in April, 1973.
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Schrijen, F., Ehrlich, W. & Permutt, S. Cardiovascular changes in conscious dogs during spontaneous deep breaths. Pflugers Arch. 355, 205–215 (1975). https://doi.org/10.1007/BF00583684
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DOI: https://doi.org/10.1007/BF00583684