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Antonie van Leeuwenhoek

, Volume 59, Issue 4, pp 215–223 | Cite as

Changes in pulmonary surfactant during bacterial pneumonia

  • Kim A. Brogden
Mini-review

Abstract

In pneumonia, bacteria induce changes in pulmonary surfactant. These changes are mediated by bacteria directly on secreted surfactant or indirectly through pulmonary type II epithelial cells. The bacterial component most likely responsible is endotoxin since gram-negative bacteria more often induce these changes than gram-positive bacteria. Also, endotoxin and gram-negative bacteria induce similar changes in surfactant. The interaction of bacteria or endotoxin with secreted surfactant results in changes in the physical (i.e. density and surface tension) properties of surfactant. In addition, gram-negative bacteria or endotoxin can injure type II epithelial cells causing them to produce abnormal quantities of surfactant, abnormal concentrations of phospholipids in surfactant, and abnormal compositions (i.e. type and saturation of fatty acids) of PC. The L/S ratio, the concentration of PG, and the amount of palmitic acid in PC are all significantly lower. The changes in surfactant have a deleterious effect on lung function characterized by significant decreases in total lung capacity, static compliance, diffusing capacity, and arterial PO2 and a significant increase in mean pulmonary arterial pressure. Also decreased concentrations of surfactant or an altered surfactant composition can result in the anatomic changes commonly seen in pneumonia such as pulmonary edema, hemorrhage, and atelectasis.

Key words

bacterial pneumonia endotoxin lipopolysaccharide lung pulmonary surfactant 

Abbreviations

BAL

Bronchoalveolar lavage

LPS

lipopolysaccharide

PC

phosphatidylcholine

PG

phosphatidylglycerol

PE

phosphatidylethanolamine

PI

phosphatidylinositol

PS

phosphatidylserine

LPC

lysophosphatidylcholine

SPH

sphingomyelin

DPPC

dipalmitoylphosphatidylcholine

L/S

lecithin/sphingomyelin

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References

  1. Albert RK, Lakshminarayan S, Hildebrandt J, Kirk W & Butler J (1979) Increased surface tension favors pulmonary edema formation in anesthetized dogs' lungs. J. Clin. Invest. 63: 1015–1018Google Scholar
  2. Aracil FM, Bosch MA & Municio AM (1985) Influence of E. coli lipopolysaccharide binding to rat alveolar Type II cells on their functional properties. Molec. Cellular Biochem. 68: 59–66Google Scholar
  3. Barrow RE & Hills BA (1979) A critical assessment of the Wilnelmy method in studying lung surfactants. J. Physiol. 295: 217–227Google Scholar
  4. Baughman RP, Stein E, MacGee J, Rashkin M & Sahebjami H (1984) Changes in fatty acids in phospholipids of the bronchoalveolar fluid in bacterial pneumonia and in adult respiratory distress syndrome. Clin. Chem. 30: 521–523Google Scholar
  5. Bosch MA, Risco C & Martin-Municio A (1990) Effect of Escherichia coli lipopolysaccharide on phosphatidylcholine biosynthesis by rat lung and alveolar type II cells. Mol. Cel. Biochem. 93: 167–172Google Scholar
  6. Brogden KA, Cutlip RC & Lehmkuhl HD (1986a) Complexing of bacterial lipopolysaccharide with lung surfactant. Infect. Immun. 52: 644–649Google Scholar
  7. Brogden KA & Hills BA (1986) Surface tension properties of pulmonary surfactant and lipopolysaccharide mixtures. Proceedings XIV International Congress of Microbiology, Manchester, England. (p 64)Google Scholar
  8. Brogden KA, Rimler RB, Cutlip RC, Lehmkuhl HD (1986b) Incubation of Pasteurella haemolytica and Pasteurella multocida lipopolysaccharide with sheep lung surfactant. Am. J. Vet. Res. 47: 727–729Google Scholar
  9. Brogden KA, Adlam C, Lehmkuhl HD, Cutlip RC, Knights JM & Engen RL (1989) Effect of Pasteurella haemolytica (A1) capsular polysaccharide on sheep lung in vivo and on pulmonary surfactant in vitro. Am. J. Vet. Res. 50: 555–5591Google Scholar
  10. Clements JA & Tierney DF (1965) Alveolar instability associated with altered surface tension. In: Fenn WO & Rahn H (Ed) Respiration (pp 1565–1583) American Physiological Society, Washington, DCGoogle Scholar
  11. Coalson JJ, King RJ, Winter VT, Prihoda TJ, Anzueto AR, Peters JI & Johanson WGJr (1989) O2− and pneumonia-induced lung injury I. Pathological and morphometric studies. J. Appl. Physiol. 67: 346–356Google Scholar
  12. Cotton DB & Hills BA (1984) Pulmonary surfactant: Hydorphobic nature of the mucosal surface of the human amnion. J. Physiol. 349: 411–418Google Scholar
  13. DeLucca AJII, Brogden KA & Engen R (1988) Enterobacter agglomerans lipopolysaccharide-induced changes in pulmonary surfactant as a factor in the pathogenesis of Byssinosis. J. Clin. Microbiol. 26: 778–780Google Scholar
  14. Dobbs LG (1989) Pulmonary surfactant. Ann. Rev. Med. 40: 431–436Google Scholar
  15. Groniowski JA (1983) Fine structural basis of pulmonary surfactant. Inter. Rev. Exper. Path. 25: 183–238Google Scholar
  16. Hallman M, Spragg R, Harrell JH, Moser KM & Gluck L (1982) Evidence of lung surfactant abnormality in respiratory failure. Study of bronchoalveolar lavage phospholipids, surface activity, phospholipase activity, and plasma myoinositol. J. Clin. Invest. 70: 673–683Google Scholar
  17. Hallman M, Arjomaa P, Tahvanainen J, Lachmann B & Spragg R (1985) Endobronchial surface active phospholipids in various pulmonary diseases. Eur. J. Resp. Dis. Suppl. 142: 37–47Google Scholar
  18. Hills BA (1988) The Biology of Surfactant. Cambridge University Press, CambridgeGoogle Scholar
  19. Holm BA, Notter RH & Finkelstein JN (1985) Surface property changes from interactions of albumin with natural lung surfactant and extracted lung lipids. Chem. Phys. Lipids 38: 287–298Google Scholar
  20. Jobe A, Ikegami M, Sarton-Miller I & Barajas L (1980) Surfactant metabolism of newborn lamb lungs studied in vivo. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 49: 1091–1098Google Scholar
  21. Kalina M & Socher R (1990) Internalization of pulmonary surfactant into lamellar bodies of cultured rat pulmonary type II cells. J. Histochem. Cytochem. 38: 483–492Google Scholar
  22. King RJ, Coalson JJ, Seidenfeld JJ, Anzueto AR, Smith DB & Peters JI (1989) O2-and pneumonia-induced lung injury. II. Properties of pulmonary surfactant. J. Appl. Physiol. 67: 357–365Google Scholar
  23. Lopez A, Albassam M, Yong S, Sharma A, Lillie LE & Prior MG (1987) Profiles of Type-II pneumocytes in rats inoculated intratracheally with bacterial lipopolysaccharide. Am. J. Vet. Res. 10: 1534–1539Google Scholar
  24. McArthur HAI & Ceri H (1983) Interaction of a rat lung lectin with the polysaccharides of Pseudomonas aeruginosa. Infect. Immun. 42: 574–578Google Scholar
  25. Magoon MW, Wright JR, Baritussio A, Williams MC, Goerke J, Benson BJ, Hamilton RL & Clements JA (1983) Subfractionation of lung surfactant. Implications for metabolism and surface activity. Biochim. Biophys. Acta 750: 18–31Google Scholar
  26. Possmayer F, Yu SH, Weber JM & Harding PGR (1984) Pulmonary surfactant. Can. J. Biochem. Cell Biol. 62: 1121–1133Google Scholar
  27. Possmayer F (1988) A proposed nomenclature for pulmonary surfactant-associated proteins. Am. Rev. Respir. Dis. 138: 990–998Google Scholar
  28. Reynolds HY (1983) Lung Inflammation: Rode of endogenous chemotactic factos in attracting polymorphonuclear granulocytes. Am. Rev. Respir. Dis. 127: S16-S25Google Scholar
  29. Rooney SA (1985) The surfactant system and lung phospholipid biochemistry. Am. Rev. Respir. Dis. 131: 439–460Google Scholar
  30. Rooney SA (1984) Lung surfactant. Environ. Health Perspectives 55: 205–226Google Scholar
  31. Rose M & Lindberg DAB (1968) Effect of pulmonary pathogens on surfactant. Diseases of the Chest 53: 541–544Google Scholar
  32. Sachse K (1989) Changes in the relative concentrations of surfactant phospholipids in young pigs with experimental pneumonia. J. Vet. Med. 36: 385–390Google Scholar
  33. Shelley SA, Paciga JE & Balis JU (1984) Lung surfactant phospholipids in different animal species. Lipids 19: 857–862Google Scholar
  34. Shimizu CSN & Mahour GH (1976) Effect of endotoxins on rabbit alveolar phospholipids. J. Surgical Res. 20: 25–32Google Scholar
  35. Sutnick AI & Soloff LA (1964) Atelectasis with pneumonia. A pathophysiologic study. Ann. Internal Med. 60: 39–46Google Scholar
  36. Tahvanainen J & Hallman M (1987) Surfactant abnormality after endotoxin-induced lung injury in guinea-pigs. Eur. J. Respir. Dis. 71: 250–258Google Scholar
  37. VanGolde LMG, Batenburg JJ & Robertson B (1988) The pulmonary surfactant system: Biochemical aspects and functional significance. Physiol. Rev. 68: 374–455Google Scholar
  38. VonWichert PV & Wilke A (1976) Alveolar stability and phospholipid content in normal pig lungs and in pig lungs with mycoplasma pneumonia. Scand. J. Resp. Dis. 57: 25–30Google Scholar
  39. Wright JR & Clements JA (1987) Metabolism and turnover of lung surfactant. Am. Rev. Respir. Dis. 135: 426–444Google Scholar

Copyright information

© Kluwer Academic Publishers 1991

Authors and Affiliations

  • Kim A. Brogden
    • 1
  1. 1.Respiratory Disease Research Unit, National Animal Disease Center, Agricultural Research ServiceU.S. Department of AgricultureAmesUSA

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