Advertisement

Pflügers Archiv

, Volume 365, Issue 1, pp 81–87 | Cite as

Renal effects of furosemide in glycerol induced acute renal failure of the rat

  • J. Greven
  • H. Klein
Article

Summary

The renal effects of furosemide in acute renal failure of the rat were studied using clearance and micropuncture techniques. Acute renal failure was induced by an intramuscular injection of 50% glycerol (10 ml/kg). Functional impairement of the glycerol treated animals consisted of a decrease in urinary sodium excretion, renal blood flow, total kidney GFR and effective filtration pressure of superficial nephrons. Effective filtration pressure was calculated from proximal free flow and stop flow pressure measurements.

In contrast to control animals furosemide did not increase urine volume during acute renal failure due to a marked fall in GFR. Renal blood flow, as measured by an electromagnetic flowmeter, also decreased after furosemide in glycerol treated rats and increased in control animals. Furosemide reduced effective filtration pressure during acute renal failure to almost zero, whereas in control animals effective filtration pressure virtually remained constant.

Key words

Renal failure Micropuncture Diuretics Glomerular filtration rate Effective filtration pressure Renal blood flow 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ayer, G., Grandchamp, A., Wyler, T., Truninger, B.: Intrarenal hemodynamics in glycerol induced myohemoglobinuric acute renal failure. Circulat. Res.29, 128–135 (1971)Google Scholar
  2. 2.
    Bailey, R. R., Natale, R., Turnbull, D. I., Linton, A. L.: Protective effect of furosemide in acute tubular necrosis and acute renal failure. Clin. Sci. molec. Med.45, 1–17 (1973)Google Scholar
  3. 3.
    Beroniade, V.: Furosemide in acute and chronic renal failure. Proc. Europ. Dialysis Transpl. Ass.5, 241–245 (1961)Google Scholar
  4. 4.
    Brown, T. C., Davis, J. O., Johnston, C. J.: Acute response in plasma renin and aldosterone secretion to diuretics. Amer. J. Physiol.211, 437–441 (1966)Google Scholar
  5. 5.
    Cantaronich, F., Locatelli, A., Fernandez, J. C., Loredo, J. P., Christhot, J.: Furosemide in high doses in the treatment of acute renal failure. Postgrad med. J., Suppl., 13–17 (1971)Google Scholar
  6. 6.
    Epstein, M., Schneider, N. S., Beteler, B.: Effect of intrarenal furosemide on renal function and intrarenal hemodynamics in acute renal failure. Amer. J. Med.58, 510–517 (1975)Google Scholar
  7. 7.
    Fein, H.: Microdimensional pressure measurements in electrolytes. J. appl. Physiol.32, 560–564 (1972)Google Scholar
  8. 8.
    Finck, E. S.: Experimental acute tubular nephrosis following subcutaneous injection of glycerol. J. Path. Bact.73, 69–85 (1957)Google Scholar
  9. 9.
    Fraser, R., James, V. H. T., Brown, J. J., Issaac, P., Lever, A. F., Robertson, J. J. S.: Effect of angiotensin and of furosemide on plasma aldosterone, corticosterone, cortisol and renin in man. Lancet1965 II, 989–991Google Scholar
  10. 10.
    Fries, D., Pozet, N., Dubois, N., Traeger, J.: The use of large doses of furosemide in acute renal failure. Postgrad. med. J. Suppl., 18–29 (1971)Google Scholar
  11. 11.
    Führ, J., Kaczmarczyk, J., Krüttgen, C. D.: Eine einfache Methode zur Inulin-Bestimmung für Nieren-Clearance-Untersuchung bei Stoffwechselgesunden und Diabetikern. Klin. Wschr.33, 729–730 (1955)Google Scholar
  12. 12.
    Fülgraff, G., Greven, J., Meiforth, A., Osswald, H.: Hydrostatische Drucke in proximalen und distalen Konvoluten und in peritubulären Kapillaren von Rattennieren nach Furosemid und Acetazolamid. Naunyn-Schmiedeberg's Arch. Pharmak.264, 76–85 (1969)Google Scholar
  13. 13.
    Gerhard, H., Mulron, P. J.: The effect of acute renal failure on renal prostaglandin A (PGA). Clin. Res.22, 528A (1974)Google Scholar
  14. 14.
    Gertz, K. H., Mangos, J. A., Braun, G., Pagel, H. D.: Pressure in the glomerular capillaries of the rat kidney and its relation to arterial blood pressure. Pflügers Arch. ges. Physiol.288, 369–374 (1966)Google Scholar
  15. 15.
    Gottschalk, C. W., Mylle, M.: Micropuncture study of pressures in proximal and distal tubules and peritubular capillaries of the rat kidney during osmotic diuresis. Amer. J. Physiol.189, 323–330 (1957)Google Scholar
  16. 16.
    Krause, H. H., Dume, T., Koch, K. M., Ochwadt, B.: Intratubulärer Druck, glomerulärer Kapillardruck und Glomerulumfiltration nach Furosemid und Hydrochlorothiazid. Pflügers Arch. ges. Physiol.295, 80–90 (1967)Google Scholar
  17. 17.
    Lonigro, A. J., Terragno, N. A., Malik, K. U., McGiff, J. C.: Differential inhibition by prostaglandins of the renal actions of pressor stimuli. Prostaglandins3, 595–606 (1973)Google Scholar
  18. 18.
    Oken, D. E., Arce, M. L., Wilson, D. R.: Glycerol induced hemoglobinuric acute renal failure in the rat. I. Micropuncture study of the development of oliguria. J. clin. Invest.45, 724–735 (1966)Google Scholar
  19. 19.
    Oken, D. E., DiBona, G. F., McDonald, F. D.: Micropuncture studies of the recovery phase of myohemoglobinuric acute renal failure in the rat. J. clin. Invest.49, 730–737 (1970)Google Scholar
  20. 20.
    Steinhausen, M.: Eine Methode zur Differenzierung proximaler und distaler Tubuli der Nierenrinde von Ratten in vivo und ihre Anwendung zur Bestimmung tubulärer Strömungsgeschwindigkeiten. Pflügers Arch. ges. Physiol.227, 23–35 (1963)Google Scholar
  21. 21.
    Thiel, G., McDonald, F. D., Oken, D. E.: Micropuncture studies of the basis for protection of renin depleted rats from glycerol induced renal failure. Nephron7, 67–79 (1970)Google Scholar
  22. 22.
    Thiel, G., Wilson, D. R., Arce, M. L., Oken, D. E.: Glycerol induced hemoglobinuric acute renal failure in the rat. II. The experimental model predisposing factors and pathophysiologic features. Nephrons4, 276–297 (1967)Google Scholar
  23. 23.
    Torres, V. E., Strong, C. G., Romero, J. C., Wilson, D. M.: Indomethacin enhancement of glycerol induced acute renal failure in rabbits. Kidney Int.7, 170–178 (1975)Google Scholar
  24. 24.
    Williamson, H. E., Bourland, W. A., Marchand, G. R.: Inhibition of furosemide induced increase in renal blood flow by indomethacin. Proc. Soc. exp. Biol. (N.Y.)148, 164–186 (1975)Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • J. Greven
    • 1
  • H. Klein
    • 1
  1. 1.Abteilung Pharmakologie, Medizinische FakultätTechnische Hochschule AachenAachenGermany

Personalised recommendations