The inhibitory effect of reserpine on the active sodium transport across the frog bladder
The effects of reserpine and harman derivatives on the sodium transport across the frog bladder were examined using a short-circuit current method. The effects of harman derivatives on the Na,K-ATPase activity of the frog kidney were also investigated.
Reserpine and harman derivatives inhibited active sodium transport of the frog bladder and their inhibitory effect decreased as reserpine>harmine >harmaline=harman>harmalol.
Harman derivatives inhibited Na,K-ATPase activity of the frog kidney.
These results suggest that reserpine and harman derivatives inhibit active sodium transport by suppressing the Na,K-ATPase activity of the frog bladder.
Key wordsReserpine Active sodium transport Na,K-ATPase Frog bladder
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