Pflügers Archiv

, Volume 361, Issue 2, pp 175–181 | Cite as

Comparison of vasoactive intestinal peptide (VIP) and secretin in gastric secretion and mucosal blood flow

  • Stanislaw J. Konturek
  • Artur Dembiński
  • Piotr Thor
  • Ryszard Król


VIP and secretin were compared in regard to their effects on gastric acid and pepsin secretion induced by pentagastrin histamine or a peptone meal as well as on gastric mucosal blood flow and meal induced serum gastrin level in conscious dogs provided with gastric fistulas and denervated fundic pouches. Both VIP and secretin caused a dose-related stimulation of basal pepsin outputs and inhibition of pentagastrin-induced acid secretion. VIP, like secretin, inhibited pentagastrin and meal-induced gastric acid secretion but in contrast to secretin it caused inhibition of acid response to histamine. Inhibition of acid secretion by VIP or secretin was accompanied by secondary reduction in gastric mucosal blood flow in tests with pentagastrin or histamine and by depression of the serum gastrin level in tests with a peptone meal. This study indicates that in comparison with secretin, VIP has a wider spectrum of inhibition of stimulated gastric secretion and may be considered as one of the enterogastrones released in the small intestine.

Key words

VIP Secretin Acid Pepsin Gastrin Mucosal blood flow 


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  1. 1.
    Anson, M. L.: The estimation of pepsin, trypsin, papain and cathepsin with hemoglobin. J. gen. Physiol.22, 79–89 (1938)Google Scholar
  2. 2.
    Barbezat, G. O., Grossman, M. I.: Intestinal secretin; stimulation by peptides. Science174, 422–424 (1971)Google Scholar
  3. 3.
    Brooks, A. M., Stening, G. P., Grossman, M. I.: Effect of gastric vagal denervation on inhibition of acid secretion by gastrin. Amer. J. dig. Dis.16, 193–202 (1971)Google Scholar
  4. 4.
    Brown, J. C., Dryburgh, J. R.: A gastric inhibitory polypeptide. II. The complete amino acid sequence. Canad. J. Biochem.49, 867–872 (1971)Google Scholar
  5. 5.
    Gregory, R. A.: Gastric secretory responses after portal venous ligation. J. Physiol. (Lond.)144, 123–127 (1958)Google Scholar
  6. 6.
    Grossman, M. I.: Gastrin, cholecystokinin, and secretin act on one receptor. Lancet1970I, 1088–1089Google Scholar
  7. 7.
    Grossman, M. I.: Spectrum of biological actions of gastrointestinal hormones. Nobel Symposium XVI: Frontiers in gastrointestinal hormone research. Stockholm: Almquist and Wiksell 1973Google Scholar
  8. 8.
    Grossman, M. I.: Candidate of hormones of the gut. Gastroenterology67, 730–755 (1974)Google Scholar
  9. 9.
    Jacobson, E. D., Lindford, R. H., Grossman, M. I.: Gastric secretion in regulation to mucosal blood flow studied by a clearance technique. J. clin. Invest.45, 1–13 (1967)Google Scholar
  10. 10.
    Jacobson, F. D., Swan, K. G., Grossman, M. I.: Blood flow and secretion in the stomach. Gastroenterology52, 414–420 (1967)Google Scholar
  11. 11.
    Johnson, L. R.: Effect of gastric mucosal acidification on the action of pepsigogues. Amer. J. Physiol.225, 1411–1415 (1973)Google Scholar
  12. 12.
    Johnson, L. R., Grossman, M. I.: Secretin: The enterogastrone released by acid in the duodenum. Amer. J. Physiol.215, 885–888 (1968)Google Scholar
  13. 13.
    Johnson, L. R., Grossman, M. I.: Characteristics of inhibition of gastric secretion by secretin. Amer. J. Physiol.217, 1401–1404 (1969)Google Scholar
  14. 14.
    Johnson, L. R., Harrison, L. A.: Comparison of exogenous secretion and duodenal acidification on pepsin secretin in dogs. Amer. J. Physiol.221, 784–787 (1971)Google Scholar
  15. 15.
    Konturek, S. J., Biernat, J., Oleksy, J.: Serum gastrin and acid response to meals at various pH levels in man. Gut15, 526–530 (1974)Google Scholar
  16. 16.
    Konturek, S. J., Tasler, J., Obtulowicz, W., Rehfeld, J. F.: Effect of metiamide, a histamine H2 receptor antagonist on mucosal blood flow and serum gastrin level. Gastroenterology66, 982–986 (1974)Google Scholar
  17. 17.
    Kosaka, T., Lim, R. K. S.: On the mechanism of the inhibition of gastric secretion by fat. The role of bile and cystokinin. Chinese J. Physiol.4, 213–220 (1930)Google Scholar
  18. 18.
    Northrup, J. H., Kunitz, M., Herriot, R. M.: Crystalline enzymes. New York: Columbia Univ. Press 1948Google Scholar
  19. 19.
    Pratt, C. L. G.: The influence of secretin on gastric secretion. J. Physiol. (Lond.)98, 1–2P (1940)Google Scholar
  20. 20.
    Schorr, B. A., Said, S. I., Makhlouf, G. M.: Inhibition of gastric secretion by synthetic vasointestinal peptide (VIP). Clin. Res.22, 22a (1974)Google Scholar
  21. 21.
    Snedecor, G. W.: Statistical methods. Ames: The Iowa State College Press 1946Google Scholar
  22. 22.
    Thomas, S. E.: An improved cannula for gastric and intestinal fistulas. Proc. Soc. exp. Biol. (N. Y.)46, 260–261 (1941)Google Scholar
  23. 23.
    Thompson, J. C., Reeder, D. D., Bunchman, H. H., Becker, H. D., Brandt, E. N.: Effect of secretin on circulating gastrin. Ann. Surg.176, 384–393 (1972)Google Scholar
  24. 24.
    Vagne, M., Stening, G. F., Brooks, F. P., Grossman, M. I.: Synthetic secretin: comparison with natural secretin for potency and spectrum of physiological actions. Gastroenterology55, 260–271 (1968)Google Scholar
  25. 25.
    Wormsley, K. G., Grossman, M. I.: Inhibition of gastric acid secretion by secretin and by endogenous acid in the duodenum. Gastroenterology47, 72–81 (1964)Google Scholar
  26. 26.
    Yalow, R. S., Berson, S. A.: Radioimmunoassay of gastrin. Gastroenterology58, 1–14 (1970)Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Stanislaw J. Konturek
    • 1
  • Artur Dembiński
    • 1
  • Piotr Thor
    • 1
  • Ryszard Król
    • 1
  1. 1.Institute of PhysiologyKrakówPoland

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