Pflügers Archiv

, Volume 403, Issue 1, pp 112–114 | Cite as

Evidence for an increase in membrane conductance during adenosine triphosphate-induced depolarization in the guinea-pig vas deferens

  • M. Wakui
  • H. Inomata
Excitable Tissues and Central Nervous Physiology Short Communications


The effects of exogenously applied adenosine triphosphate (ATP) on the smooth muscle of guinea-pig vas deferens were studied with the double sucrose-gap method. ATP evoked a membrane depolarization which was associated with a decrease in the size of electrotonic potentials. Conditioning hyperpolarization induced by current application caused an increase in the magnitude of the ATP-induced depolarization; the larger the conditioning hyperpolarization, the greater the ATP-induced depolarization. These results are discussed with respect to the ionic mechanism of the electrical event in response to ATP in this tissue.

Key words

guinea-pig vas deferens adenosine triphosphate depolarization membrane conductance ATP reversal potential 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • M. Wakui
    • 1
  • H. Inomata
    • 1
  1. 1.Department of Applied PhysiologyTohoku University School of MedicineSendai, MiyagiJapan

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