Pflügers Archiv

, Volume 403, Issue 1, pp 109–111 | Cite as

Decrease in membrane conductance induced by noradrenaline in the smooth muscle of guinea-pig vas deferens

  • M. Wakui
  • H. Inomata
Excitable Tissues and Central Nervous Physiology Short Communications


The electrical response of the smooth muscle of guinea-pig vas deferens to exogenously applied noradrenaline (NA) was examined using the double sucrose-gap method. NA evoked a depolarization of the smooth muscle membrane which was associated with an increase in the size of electrotonic potentials. A conditioning depolarization of the membrane induced by current application enhanced the size of NA-induced depolarization, whereas a conditioning hyperpolarization reduced it. When a conditioning hyperpolarization of 25 mV in magnitude was applied, the direction of potential change induced by NA was reversed. These results are discussed with respect to the ionic mechanism of the electrical event in response to NA in this tissue.

Key words

guinea-pig vas deferens noradrenaline depolarization membrane conductance NA reversal potential 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • M. Wakui
    • 1
  • H. Inomata
    • 1
  1. 1.Department of Applied PhysiologyTohoku University School of MedicineSendai MiyagiJapan

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