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Pflügers Archiv

, Volume 403, Issue 1, pp 28–34 | Cite as

Stimulation by glucagon and PTH of Ca and Mg reabsorption in the superficial distal tubule of the rat kidney

  • C. Bailly
  • N. Roinel
  • C. Amiel
Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands

Abstract

The effects of glucagon and PTH on electrolyte reabsorption in the distal tubule were investigated in rats deprived of vasopressin, calcitonin, PTH, and glucagon. Micropunctures of distal tubule, at a late and an early site of a same nephron, have been performed in 23 rats, nine control, seven infused with glucagon (5 ng·min−1·100 g−1 b.w.) and seven with PTH (5 mU·min−1·100 g−1 b.w.). The Ca and Mg reabsorptive capacity of the distal segment was increased by glucagon and by PTH. Moreover, fractional Na and Cl reabsorption was significantly higher than in control during PTH administration. A K secretion appeared during the administration of both hormones. No phosphate net transport was observed in any group. Finally, the data presented here, together with those previously reported, indicate that the increase of Ca and Mg renal reabsorption observed with glucagon and PTH results from an effect located in both Henle's loop, where the bulk of Ca and Mg is reabsorbed, and the distal tubule.

Keywords

Phosphate Human Physiology Glucagon Calcitonin Vasopressin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • C. Bailly
    • 1
  • N. Roinel
    • 2
  • C. Amiel
    • 1
  1. 1.Unité INSERM 251, Département de Physiologie, Faculté Xavier BichatUniversité Paris 7ParisFrance
  2. 2.Laboratoire de Physiologie Physico-Chimique, Département de BiologieCentre d'Etudes Nucléaires de SaclayGif-sur-Yvette, CedexFrance

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