Summary
Acute conditioned skin necrosis in rats, induced by systemic administration of dextran and local injection of a normally well-tolerated dosis of dilute acetic acid, can be inhibited by pretreatment with glucose of alloxan. This condition can be aggravated by fasting or insulin.
Zusammenfassung
Die akute konditionierte Hautnekrose bei Ratten, hervorgerufen durch eine systemische Verabreichung von Dextran und eine lokale Injektion von einer normalerweise gut vertragenen Dosis verdünnter Essigsäure, kann durch Vorbehandlung mit Glucose oder Alloxan verhütet werden. Die Gewebeschädigung kann durch Vorbehandlung mit Hungern oder Insulin verschlimmert werden.
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References
Adamkiewicz, V. W.: Glycemia and immune responses. Canad. med. Ass. J.88, 806–811 (1963)
Adamkiewicz, V. W., Adamkiewicz, L. M.: Glucose and the dextran “anaphylactoid” inflammation. Amer. J. Physiol.198, 51–53 (1960)
Adamkiewicz, V. W., Fitko, R. J., Fortier, A. A.: Hypoglycemic drugs and the dextran “anaphylactoid” inflammation. Canad. J. Biochem.38, 823–827 (1960)
Adamkiewicz, V. W., Langlois, Y. L.: Sensitization by insulin to the dextran “anaphylactoid” reaction. Canad. J. Biochem.35, 251–256 (1957)
Adamkiewicz, L. M., Adamkiewicz, V. W.: Glucagon, insulin and “anaphylactoid” inflammation. J. Physiol. (Lond.)145, 667–670 (1959)
Edlund, T., Löfgren, B., Vali, L.: Toxicity of dextran in rats. Nature (Lond.)170, 125 (1952)
Folin-Wu: Method. In: Kolmer, J. A., Spaulding, E. H., and Robinson, H. W.: Approved Laboratory Technic, p. 585. New York: Appleton 1951
Goth, A., Nash, W. L., Nagler, M., Holman, J.: Inhibition of histamine release in experimental diabetes. Amer. J. Physiol.191, 25–28 (1957)
Jasmin, G., Bois, P.: Effect of insulin, fasting and tolbutamide on dextran edema in rats. Proc. Soc. exp. Biol. (N.Y.)101, 656–658 (1959)
Rohan, P., Scholz, W. H.: Effect of insulin or fasting on anaphylactoid oedema and acute conditioned necrosis. Exc. Med. (Amsterdam), Int. Congr. Ser. No.211, p. 27 (1970)
Selye, H.: The mast cells. Washington: Butterworth 1965
Selye, H.: Anaphylactoid edema. St. Louis: Warren H. Green 1968
Selye, H.: Stress. Montreal: Acta Inc., Med. Publ. 1950
Selye, H.: Calciphylaxis. Chicago, Ill.: The University of Chicago Press 1962
Selye, H., Rohan, P.: Humoral conditioning for necrosis, Part II. The challengers. Naunyn-Schmiedeberg's Arch. Pharmak. exp. Path.255, 142–150 (1966)
Selye, H., Rohan, P., Pahk, U. S.: Humoral conditioning for necrosis. Part I. The conditioning factors. Naunyn-Schmiedeberg's Arch. Pharmak. exp. Path.255, 133–141 (1966)
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M. D., Moncton City Hospital, Moncton, N.B.
M. D., Ph. D., Assoc. Prof., Université de Montréal, Dept. of Pathology, Montréal.
M. D., Montreal General Hospital, Montreal.
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Rohan, P., Scholz, W.H., Solymoss, B. et al. Influence of some glycemia-affecting factors on acute (Conditioned) cutaneous necrosis. Arch. Derm. Res. 250, 121–125 (1974). https://doi.org/10.1007/BF00582766
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DOI: https://doi.org/10.1007/BF00582766