Antonie van Leeuwenhoek

, Volume 62, Issue 3, pp 225–230 | Cite as

Hyalohyphomycosis caused byPaecilomyces variotii: a case report, animal pathogenicity and ‘in vitro’ sensitivity

  • Jaishree Naidu
  • S. M. Singh


A case of cutaneous infection in a 25-year-old male caused byPaecilomyces variotii is described. Animal pathogenicity studies with normal and cortisone-treated mice revealed the predeliction ofP. variotii for skin and liver in both normal and cortisone-treated mice and for lungs and heart only in immunosuppressed mice. 5-fluorocytosine gave the best MIC value forP. variotii in vitro. This report documents for the first time thatP. variotii causes cutaneous infection.

Key words

Hyalohyphomycosis Paecilomyces variotii 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Arai H & Endo T (1977) A case of deep mycosis (Fonsecaea pedrosoi andPaecilomyces lilacinus) following renal transplant. Hifuka (Clinical Dermatology) 31: 481–487Google Scholar
  2. Ajello L & McGinnis MR (1984) Nomenclature of human pathogenic fungi. In: Krasifini, Kow AP, Kramer A, Groschel D & Wenffer W (Eds) Grundlagen der Antiseptic Band 1, Teil 4 (pp 363–377). Berlin, Verlag Volk und GesundheitGoogle Scholar
  3. Castro LGM, Salebian A & Sotto MN (1990) Hyalohyphomycosis byPaecilomyces lilacinus in a renal transplant patient and a review of humanPaecilomyces species infections. Journal of Medical and Veterinary Mycology 28: 15–26Google Scholar
  4. Dekkan-Khodzhaeva NA, Shamsiev SSH, Shakirova RYu, Macarova GI & Mingbaeva SHN (1982) The role ofPaecilomyces in the etiology of prolonged and recurrent bronchopulmonary diseases in children.Pediatryia 9: 12–14Google Scholar
  5. Dharmasena FMC, Davies GSR & Catovsky D (1985)Paecilomyces variotii pneumonia complicating hairy-cell leukaemia. British Medical Journal 290: 967–968Google Scholar
  6. Fagerburg R, Suh B, Buckley HR, Lorber B & Karian J (1981) Cerebro spinal fluid shunt colonization and obstruction byPaecilomyces variotii. Journal of Neurosurgery 54: 257–260Google Scholar
  7. Fenech FF & Mallia CP (1972) Pleural effusion caused byPenicillium lilacinum. British Journal of diseases of the Chest 66: 284–290Google Scholar
  8. Forster RK & Rebell G (1975) The diagnosis and management of keratomycosis II. Medical and surgical management. Archieves of Ophthalmology 93: 1134–1136Google Scholar
  9. Halde C & Okumoto M (1966) Ocular mycosis: a study of 82 cases. Proceedings of the XX International Congress of Ophthalmology, Munich. Excerpta Medica International Congresses Series 146: 705–715Google Scholar
  10. Haley LD & McCabe A (1950) A mycologic study of seventy one autopsies. American Journal of Clinical Pathology 20: 35–38Google Scholar
  11. Harris LF, Dan BM, LefkowitzJr LB & Alford RH (1979)Paecilomyces cellulitis in a renal transplant patient: successful treatment with intravenous miconazole. Southern Medical Journal 72: 897–898Google Scholar
  12. Hubalek Z & Hornich M (1977) Experimental infection of white mouse withChrysosporium andPaecilomyces. Mycopathologia 62(3): 173–178Google Scholar
  13. Jade KB, Lyons MF & GnannJr JW (1986)Paecilomyces lilacinus cellulitis in an immunocompromised patient. Archives of Dermatology 122: 1169–1170Google Scholar
  14. Jones BR (1975) Principles in the management of oculomycosis. American Journal of Ophthalmology 79: 719–751Google Scholar
  15. Kalish SB, Goldschmidt R, Li C, Knop R, Cook FV, Wilner G & Victor TA (1982) Infective endocarditis caused byPaecilomyces variotii. American Journal of Clinical Pathology 78: 249–252Google Scholar
  16. Kobayashi GS & Medoff G (1983) Measurement of activity of antifungal drug. In: Howard DH (Ed) Fungal Pathogenic for Humans and Animals Part B (357–372)Google Scholar
  17. McClellan JR, Hamilton JD, Alexander JA, Wolfe WG & Reed JB (1976)Paecilomyces variotii endocarditis on a prosthetic aortic valve. Journal of Thoracic and Cardiovascular Surgery 71: 472–475Google Scholar
  18. McGinnis MR, Ajello L & Schell WA (1985) Myotic Diseases. A proposed nomenclature. International Journal of Dermatology 24: 9–15Google Scholar
  19. Okuda C, Ito M, Sato Y, Oka K & Hotchi M (1987) Disseminated cutaneousFusarium infection with vascular invasion in a leukemic patient. Journal of Medical and Veterinary Mycology 25: 177–188Google Scholar
  20. Polak A (1983) Oxiconazole & new imidazole derivative. Evaluation of antifungal activityin vitro andin vivo. Arzeim — Forsch/Drug Research 32 (1): 17–24Google Scholar
  21. Raper KB & Thom C (1949) A Manual of the Penicillia. Williams & Wilkins, BaltimoreGoogle Scholar
  22. Ray TL (1980) Fungal infections in the immunocompromised host. Medical Clinics of North America 64: 955–968Google Scholar
  23. Refai M, El-Mansoury H & Osman MA (1971) Incidence of yeast in sputa and urine in chest disease. Mykosen 14: 299–302Google Scholar
  24. Sherwood JA & Dansky AS (1983)Paecilomyces pyelonephritis complicating nephrolithiasis and review ofPaecilomyces infections. Journal of Urology 130: 526–528Google Scholar
  25. Silver MD, Tuffnell PG & Bigelow WG (1971) Endocarditis caused byPaecilomyces variotii affecting an aortic valve allograft. Journal of Thoracic and Cardiovascular Surgery 61: 278–281Google Scholar
  26. Takayasu S, Akagi M & Shimizu Y (1977) Cutaneous mycosis caused byPaecilomyces lilacinus. Archives of Dermatology 113: 1687–1690Google Scholar
  27. Uys CJ, Don PA, Schrire V & Barnard CN (1963) Endocarditis following cardiac surgery due to the fungusPaecilomyces. South African Medical Journal 21: 1276–1280Google Scholar
  28. Zaias N, Oertel I & Elliot DF (1969) Fungi in toe nails. Journal of Investigative Dermatology 53: 140–142Google Scholar

Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • Jaishree Naidu
    • 1
  • S. M. Singh
    • 1
  1. 1.Medical Microbiology Laboratory, Department of Biological SciencesRani Durgavati UniversityJabalpurIndia

Personalised recommendations