Pflügers Archiv

, Volume 393, Issue 1, pp 104–108 | Cite as

Effect of sodium concentration and plasma sugar concentration on hexose absorption by the rat jejunum in vivo

Further evidence for two transport mechanisms
  • E. S. Debnam
Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands

Abstract

The sodium-dependency of both the saturable and non-saturable components of glucose and galactose absorption across the rat jejunum in vivo has been determined. The non-saturable process appears to be unaffected by sodium removal but when Na+ concentrations in the lumenal fluid are progressively reduced from 143 mM to 0 mM theJmax for active absorption is greatly decreased.

In a separate study these two components of glucose transport were further investigated using intravenous sugar infusion to modify the transepithelial sugar concentration gradient. When identical glucose concentrations were present in plasma and intestinal lumen, the reduction in glucose absorption was fully accounted for by the elimination of the non-saturable component from the overall absorptive process. Together, these observations can be interpreted as further evidence for the existence of at least two absorption processes in vivo. The implication for analysing results from experimental studies of intestinal sugar absorption in vivo is discussed.

Key words

Sodium Intestinal absorption Glucose transport Galactose transport Hyperglycaemia Rat jejunum 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • E. S. Debnam
    • 1
  1. 1.Department of PhysiologyRoyal Free Hospital School of MedicineLondonUK

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