Pflügers Archiv

, Volume 381, Issue 2, pp 151–157 | Cite as

Systemic hypoxia and hyperoxia, and liver blood flow and oxygen consumption in the greyhound

  • Roger L. Hughes
  • Robert T. Mathie
  • Donald Campbell
  • William Fitch
Heart, Circulation, Respiration and Blood; Environmental and Exercise Physiology

Abstract

The effects of systemic hypoxia upon liver blood flow and oxygen consumption were studied in a group of six pentobarbitone anaesthetised greyhounds. The effect of systemic hyperoxia upon the same factors were also studied in a further group of six greyhounds.

Hypoxia studied atPaO2 tensions of 9.3, 7.3, 5.3 and 3.3 kPa was found to increase mean arterial pressure significantly at eachPaO2 tension studied immediately the hypoxic gas mixture was introduced but this pressure had returned to control by the time 20 min had passed. At the same time a significant decrease in hepatic arterial blood flow was seen, returning to control by 20 min. No significant changes were seen in portal venous blood flow. Hepatic arterial and mesenteric vascular resistance increased significantly immediately hypoxia was instituted at allPaO2 tensions.

Hepatic oxygen consumption, measured after 20 min, decreased at allPaO2 tensions, significantly at 3.3 kPa (25 mm Hg). Hepatic venous oxygen content decreased significantly at eachPaO2, decreasing to 20% of control at 3.3 kPa (25 mm Hg).

Hyperoxia studied atPaO2 tensions of 26.6, 39.9 and 53.2 kPa produced no significant effects upon liver blood flow. However, there was a small increase in hepatic oxygen consumption.

Key words

Hepatic artery Portal vein Hepatic oxygen consumption Hypoxia Hyperoxia 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adachi, H., Strauss, W., Ochi, H., Wagner, H. N.: The effect of hypoxia on the regional distribution of cardiac output in the dog. Circ. Res.39, 314–319 (1976)Google Scholar
  2. Bergovsky, E. H., Bertur, P.: Responses of regional circulations to hyperoxia. J. Appl. Physiol.21, 567–572 (1966)Google Scholar
  3. Drapanas, T., Kluge, D. N., Schenk, W. G.: Measurement of hepatic blood flow by bromsulphthalein and by the electromagnetic flowmeter. Surgery43, 1017–1021 (1960)Google Scholar
  4. Eggers, G. W., Poley, H. W., Leonard, T. J.: Hemodynamic responses to oxygen breathing in man. J. Appl. Physiol.17, 75–79 (1962)Google Scholar
  5. Evringham, A., Brenneman, E. M., Horvath, S. M.: Influence of sodium pentobarbital on splanchnic blood flow and related functions. Am. J. Physiol.197, 624–626 (1959)Google Scholar
  6. Fischer, A., Takacs, L., Molnar, G.: Hepatic circulation in arterial hypoxia. Acta Med. Acad. Sci. Hung.16, 61–74 (1960)Google Scholar
  7. Fisher, B., Russ, C., Selker, R. G., Fedor, E. J.: Observations on liver blood flow — Its relationship to cardiac output in anaesthetised and unanaesthetised animals. Arch. Surg.72, 600–611 (1956)Google Scholar
  8. Galindo, A.: Hepatic circulation and hepatic function during anaesthesia and surgery. Can. Anaest. Soc. J.12, 262–274 (1965)Google Scholar
  9. Gilmore, J. P.: Effect of anesthesia and hepatic sampling site upon hepatic blood flow. Am. J. Physiol195, 465–468 (1958)Google Scholar
  10. Gilmore, J. P.: Pentobarbital sodium anesthesia in the dog. Am. J. Physiol.209, 404–408 (1965)Google Scholar
  11. Greenway, C. V., Stark, R. D.: Hepatic vascular bed. Physiol. Rev.51, 23–65 (1971)Google Scholar
  12. Hughes, R. L., Mathie, R. T., Campbell, D., Fitch, W.: The effect of hypercarbia on hepatic blood flow and oxygen consumption in the greyhound. Br. J. Anaesth.51, 289–296 (1979)Google Scholar
  13. Ishikawa, H., Matsui, H., Fukumura, J., Ito, H., Doi, M., Hayashi, M., Honjo, A.: Hepatic circulation in systemic hypoxia. Jpn. Circ. J.38, 899–905 (1974)Google Scholar
  14. Kontos, H. A., Mauch, H. P., Richardson, D. W., Patterson, J. L.: Mechanism of circulatory responses to systemic hypoxia in the anesthetised dog. Am. J. Physiol.209, 397–403 (1965)Google Scholar
  15. Krasney, J. A.: Regional circulatory responses to arterial hypoxia in the anethetised dog. Am. J. Physiol.220, 699–704 (1971)Google Scholar
  16. Kusumi, F., Butts, W. C., Ruff, W. L.: Superior analytical performance by electrolytic cell analysis of blood oxygen content. J. Appl. Physiol.35, 299–300 (1973)Google Scholar
  17. Larsen, J. A., Krarup, N., Munck, A.: Liver hemodynamics and liver function in cats during graded hypoxic hypoxaemia. Acta. Physiol. Scand.98, 257–262 (1976)Google Scholar
  18. Lutz, J., Henrich, H., Baureisen, E.: Oxygen supply and uptake in the liver and the intestine. Pflügers Arch.360, 7–15 (1975)Google Scholar
  19. Mundschau, G. A., Zimmerman, S. W., Gildersleeve, J. W., Murphy, Q. R.: Hepatic and mesenteric artery resistances after sino-aortic denervation and haemorrhage. Am J. Physiol.211, 77–82 (1966)Google Scholar
  20. Murray, J. F., Fukud, P., Jacob, P.: Hemodynamic effects of 100% oxygen in anesthetised dogs. Clin. Res.12, 204 (1964)Google Scholar
  21. Scholtholt, J., Shiraishi, T.: The reaction of liver and intestinal blood flow to a general hypoxia, hypocapnia and hypercapnia in the anesthetised dog. Pflügers Arch.318, 185–201 (1970)Google Scholar
  22. Tashkin, D. P., Goldstein, P. J., Simmons, D. M.: Hepatic lactate uptake during decreased liver perfusion and hypoxaemia. Am. J. Physiol.223, 968–974 (1972)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Roger L. Hughes
    • 1
  • Robert T. Mathie
    • 1
  • Donald Campbell
    • 1
  • William Fitch
    • 1
  1. 1.The University Departments of Anaesthesia and SurgeryGlasgow, Royal InfirmaryGlasgowUK

Personalised recommendations