Pflügers Archiv

, Volume 381, Issue 2, pp 99–105 | Cite as

Modification of feedback influence on glomerular filtration rate by acute isotonic extracellular volume expansion

  • A. Erik G. Persson
  • Jürgen Schnermann
  • Fred S. Wright
Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands


The behavior of the feedback mechanism, that causes glomerular capillary pressure and filtration rate to decrease when tubule fluid flow rate through the loop of Henle of the same nephron is increased, was examined in rats before and during isotonic extracellular fluid volume expansion. The loop of Henle was perfused from the late proximal tubule at either 10 or 40 nl/min while proximal fluid was collected to measure single nephron filtration rate (SNGFR), while proximal stop-flow pressure (PSF) was measured, or while fluid was collected from the early distal tubule to assess reabsorption of fluid and electrolytes by the loop of Henle. During control periods increasing loop perfusion caused SNGFR to decrease 37%, PSF to decrease 19%, and absorption of fluid, sodium and chloride by the loop of Henle to increase. After 1 h of infusion of isotonic NaCl solution the same change in loop flow causes a 19% decrease in SNGFR and an 8% decrease in PSF. Fluid absorption by the loop of Henle did not increase with increased loop perfusion. Increases in Na and Cl absorption were similar to the increases in control periods. The smaller decreases in SNGFR and PSF indicate that acute volume expansion decreases the sensitivity of the feedback response. The mechanism of this decrease in gain could involve interference with local generation or action of angiotensin, or a change in the composition or pressure of interstitial fluid tending to dilate the pre-glomerular resistance vessels.

Key words

Rat Micropuncture Microperfusion Loop of Henle Stop-flow pressure 


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  1. 1.
    Blantz, R. C., Konnen, K. S.: Relation of distal tubule delivery rate and reabsorptive rate to nephron filtration. Am. J. Physiol.233, F315-F324 (1977)Google Scholar
  2. 2.
    Brenner, B. M., Troy, J. L., Daugharty, T. M., Deen, W. M.: Dynamics of glomerular ultrafiltration in the rat. II. Plasma-flow dependence of GFR. Am. J. Physiol.223, 1184–1190 (1972)Google Scholar
  3. 3.
    Briggs, J. P., Wright, F. S.: Feedback control of glomerular filtration rate: site of the effector mechanism. Kidney Int.12, 552 (1977)Google Scholar
  4. 4.
    Briggs, J. P., Wright, F. S.: Feedback control of glomerular filtration rate: Site of the effector mechanism. Am. J. Physiol.236, F40-F47 (1979)Google Scholar
  5. 5.
    Burke, T. J., Navar, L. G., Clapp, J. R., Robinson, R. R.: Response of single nephron glomerular filtration rate to distal nephron microperfusion. Kidney Int.6, 230–240 (1974)Google Scholar
  6. 6.
    Cortney, M. A., Mylle, M., Lassiter, W. E., Gottschalk, C. W.: Renal tubular transport of water, solute, and PAH in rats loaded with isotonic saline. Am. J. Physiol.209, 1199–1205 (1965)Google Scholar
  7. 7.
    Dev, B., Drescher, C., Schnermann, J.: Resetting of tubuloglomerular feedback sensitivity by dietary salt intake. Plfügers Arch.346, 263–277 (1974)Google Scholar
  8. 8.
    Fein, H.: Microdimensional pressure measurements in electrolytes. J. Appl. Physiol.32, 560–564 (1972)Google Scholar
  9. 9.
    Haeberle, D.: Influence of glomerular filtration rate on the rate of para-aminohippurate secretion by the rat kidney: Micropuncture and clearance studies. Kidney Int.7, 385–396 (1975)Google Scholar
  10. 10.
    Hierholzer, K., Müller-Suur, R., Gutsche, H.-U., Butz, M., Lichtenstein, I.: Filtration in surface glomeruli as regulated by flow rate through the loop of Henle. Pflügers Arch.352, 315–337 (1974)Google Scholar
  11. 11.
    Kaufman, J. S., Hamburger, R. J., Flamenbaum, W.: Tubuloglomerular feedback: effect of dietary NaCl intake. Am. J. Physiol.231, 1744–1749 (1976)Google Scholar
  12. 12.
    Kaufman, J. S., Hamburger, R. J., Flamenbaum, W.: Effect of renin-angiotensin system activity on tubulo-glomerular feedback in the rat. Fed. Proc.35, 541 (1976)Google Scholar
  13. 13.
    Kaufman, J. S., Hamburger, R. J., Flamenbaum, W.: The effect of volume expansion, hemorrhagic hypotension, and aortic clamping on juxtaglomerular apparatus renin activity in the rat. Kidney Int.10, 531 (1976)Google Scholar
  14. 14.
    Kunau, R. T., Jr., Webb, H. L., Borman, S. C.: Characteristics of the relationship between the flow rate of tubular fluid and potassium transport in the distal tubule of the rat. J. Clin. Invest.54, 1488–1495 (1974)Google Scholar
  15. 15.
    Kunau, R. T., Jr., Webb, H. L., Borman, S. C.: Characteristics of sodium reabsorption in the loop of Henle and distal tubule. Am. J. Physiol.227, 1181–1191 (1974)Google Scholar
  16. 16.
    Landwehr, D. M., Klose, R. M., Giebisch, G.: Renal tubular sodium and water reabsorption in the isotonic sodium chloride loaded rat. Am. J. Physiol.211, 1327–1333 (1967)Google Scholar
  17. 17.
    Malnic, G., Klose, R. M., Giebisch, G.: Micropuncture study of renal potassium excretion in the rat. Am. J. Physiol.206, 674–686 (1964)Google Scholar
  18. 18.
    Mason, J.: Tubulo-glomerular feedback in early stages of experimental acute renal failure. Kidney Int.10, Suppl. 6, 106–114 (1976)Google Scholar
  19. 19.
    Morgan, T., Berliner, R. W.: A study by continuous microperfusion of water and electrolyte movements in the loop of Henle and distal tubule of the rat. Nephron6, 388–405 (1969)Google Scholar
  20. 20.
    Persson, E. G., Müller-Suur, R., Selen, G.: Peritubular capillary oncotic pressure as a modifier of tubuloglomerular feedback. Kidney Int.10, 595 (1976)Google Scholar
  21. 21.
    Persson, E. G., Selen, G., Müller-Suur, R.: Activation of the tubuloglomerular feedback in dehydrated animals. Proc. Int. Union Physiol. Sci., Vol. XIII, 589, Paris 1977Google Scholar
  22. 22.
    Ploth, D. W., Rudulph, J., La Grange, R., Navar, L. G.: Nephron function after converting enzyme inhibition in the rat. Abstracts, VIIth Int. Cong. of Nephrol. F-9, 1978Google Scholar
  23. 23.
    Ploth, D. W., Rudulph, J., Thomas, C., Navar, L. G.: Renal and tubulo-glomerular feedback responses to plasma expansion in the rat. Am. J. Physiol.235, F156-F162 (1978)Google Scholar
  24. 24.
    Ramsay, J. A., Brown, R. H. J., Croghan, P. C.: Electrometric titration of chloride in small volumes. J. Exp. Biol.32, 822–829 (1955)Google Scholar
  25. 25.
    Rouffignac, C. de, Bonvalet, J. P., Menard, J.: Renin content in superficial and deep glomeruli of normal and salt-loaded rats. Am. J. Physiol.226, 150–154 (1974)Google Scholar
  26. 26.
    Schnermann, J.: Microperfusion study of single short loops of Henle in rat kidney. Pflügers Arch.300, 255–282 (1968)Google Scholar
  27. 27.
    Schnermann, J., Levine, D. Z.: Tubular control of glomerular filtration rate in single nephrons. Can. J. Physiol. Pharmacol.53, 325–329 (1977)Google Scholar
  28. 28.
    Schnermann, J., Wright, F. S., Davis, J. M., Stackelberg, W. v., Grill, G.: Regulation of superficial nephron filtration rate by tubulo-glomerular feedback. Pflügers Arch.318, 147–175 (1970)Google Scholar
  29. 29.
    Schnermann, J., Persson, E., Ulfendahl, H., Wolgast, M., Wunderlich, P.: Functional characteristics of the renal interstitial space. In: Recent advances in renal physiology (H. Wirz, F. Spinelli, eds.), pp. 43–49. Basel: S. Karger 1972Google Scholar
  30. 30.
    Schnermann, J., Persson, A. E. G., Ågerup, B.: Tubuloglomerular feedback. Non-linear relation between glomerular hydrostatic pressure and loop of Henle perfusion rate. J. Clin. Invest.52, 862–869 (1973)Google Scholar
  31. 31.
    Schnermann, J., Hermle, M., Schmidmeier, E., Dahlheim, H.: Impaired potency for feedback regulation of glomerular filtration rate in DOCA escaped rats. Pflügers Arch.358, 325–338 (1975)Google Scholar
  32. 32.
    Schnermann, J., Ploth, D. W., Hermle, M.: Activation of tubuloglomerular feedback by chloride transport. Pflügers Arch.362, 229–240 (1976)Google Scholar
  33. 33.
    Stowe, N. T., Schnermann, J.: Renin-angiotensin mediation of tubulo-glomerular feedback control of filtration rate. Fed. Proc.33, 347 (1974)Google Scholar
  34. 34.
    Vander, A. J., Miller, R.: Control of renin secretion in the anesthetized dog. Am. J. Physiol.207, 537–546 (1964)Google Scholar
  35. 35.
    Wright, F. S., Briggs, J. P.: Feedback regulation of glomerular filtration rate. Am. J. Physiol.233, F1-F7 (1977)Google Scholar
  36. 36.
    Wright, F. S., Schnermann, J.: Interference with feedback control of glomerular filtration rate by furosemide, triflocin, and cyanide. J. Clin. Invest.53, 1695–1708 (1974)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • A. Erik G. Persson
    • 1
    • 2
  • Jürgen Schnermann
    • 1
    • 2
  • Fred S. Wright
    • 1
    • 2
  1. 1.Departments of medicine and PhysiologyYale University School of MedicineNew HavenUSA
  2. 2.Veterans Administration HospitalWest HavenUSA

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