The role of intrinsic, non-adrenergic, non-cholinergic inhibitory nerves in the regulation of distensibility of the guinea-pig colon
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The lengthening responses of segments of distal colon of guinea-pigs to applied weights were measured.
Distensibility was reduced by tetrodotoxin and quinidine; increased by atropine and hyoscine, and unaffected by guanethidine and phentolamine.
Tension changes produced by controlled stretches were increased by tetrodotoxin.
These results suggest that there is a net, inhibitory, non-adrenergic, non-cholinergic influence acting on the muscle during stretch against a background of cholinergic excitatory tone. This inhibitory activity may be activated reflexly by stretch.
Key wordsColon Intestinal motility autonomic nervous system enteric nerves
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