Pflügers Archiv

, Volume 381, Issue 1, pp 75–77 | Cite as

The role of intrinsic, non-adrenergic, non-cholinergic inhibitory nerves in the regulation of distensibility of the guinea-pig colon

  • J. S. Davison
  • G. T. Pearson
Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands Letters and Notes

Summary

  1. 1.

    The lengthening responses of segments of distal colon of guinea-pigs to applied weights were measured.

     
  2. 2.

    Distensibility was reduced by tetrodotoxin and quinidine; increased by atropine and hyoscine, and unaffected by guanethidine and phentolamine.

     
  3. 3.

    Tension changes produced by controlled stretches were increased by tetrodotoxin.

     
  4. 4.

    These results suggest that there is a net, inhibitory, non-adrenergic, non-cholinergic influence acting on the muscle during stretch against a background of cholinergic excitatory tone. This inhibitory activity may be activated reflexly by stretch.

     

Key words

Colon Intestinal motility autonomic nervous system enteric nerves 

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References

  1. Burnstock, G.: Comparative studies of purinergic nerves. J. Exp. Zool.194, 103–127 (1975)Google Scholar
  2. Burnstock, G., Campbell, G., Satchell, D. G., Smythe, A.: Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. Br. J. Pharmacol.40, 668–688 (1970)Google Scholar
  3. Furness, J. B.: An electrophysiological study of the innervation of the smooth muscle of the colon. J. Physiol. (Lond.)205, 803–821 (1969)Google Scholar
  4. Furness, J. B., Costa, M.: The participation of enteric inhibitory nerves in accommodation of the intestine to distension. Clin. Exp. Pharmacol. Physiol.4, 37–41 (1977)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • J. S. Davison
    • 1
  • G. T. Pearson
    • 1
  1. 1.Department of PhysiologyThe UniversityDundeeUK

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