Calcified Tissue International

, Volume 50, Issue 6, pp 502–506 | Cite as

Compact and trabecular components of the spine using quantitative computed tomography

  • Tamas Sandor
  • Dieter Felsenberg
  • Willi A. Kalender
  • Alisabet Clain
  • Edward Brown
Clinical Investigations


A computer algorithm was employed to quantify separately cortical and trabecular bone mineral density (BMD) from single energy computed tomography (CT) scans of 139 vertebrae (L1–L3) of 50 normal female subjects. In addition, the trabecular-to-integral and cortical-to-integral mass ratios were determined using digital image segmentation techniques. They showed that for the central 8-mm vertebral slice, the mass of integral bone consists of about one-fifth trabecular and four-fifth cortical bone. The trabecular-to-integral volume ratios were 0.37±0.08 and 0.63±0.08, respectively. Based on cross-sectional data from this subject group, the average annual loss was -2.21±0.15 mg/cm3 or-1.84±0.12% for trabecular bone, -3.15±0.25 mg/cm3 or-1.01±0.08% for cortical bone, and -2.60±0.20 mg/cm3 or -1.09±0.09% for the integral bone. The proportions of the age-related los of BMD from the integral bone which originated from trabecular and cortical bone were 29.5 and 70.5%, respectively.

Key words

Quantitative CT Bone mineral density Bone densitometry Spinal mineral density 


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Copyright information

© Springer-Verlag New York Inc 1992

Authors and Affiliations

  • Tamas Sandor
    • 1
  • Dieter Felsenberg
    • 3
  • Willi A. Kalender
    • 4
  • Alisabet Clain
    • 1
  • Edward Brown
    • 2
  1. 1.Department of Radiology, Harvard Medical SchoolBrigham and Women's HospitalBostonUSA
  2. 2.Endocrine-Hypertension Division, Department of Medicine, Harvard Medical SchoolBrigham and Women's HospitalBostonUSA
  3. 3.Department of Radiology, Klinikum SteglitzFreie UniversitaetBerlinGermany
  4. 4.Siemens Medical SystemsErlangenGermany

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