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The influence of the surface electrogram on the rising phase of the mammalian cardiac action potential

  • Excitable Tissues and Central Nervous Physiology
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Abstract

  1. 1.

    When guinea pig cardiac tissue is stimulated, the rising phase of the action potential is influenced by the shape of the concomitant local surface electrogram. This, in turn, depends on the direction of the wave of excitation passing the recording microelectrode.

  2. 2.

    A symmetrical biphasic surface electrogram yields sigmoid upstrokes with maximum upstroke velocity (V max) lower than when it is either zero or uniphasic and negative.

  3. 3.

    When the main direction of the depolarization wave in guinea pig ventricular myocardium is receding from the recording microelectrode, giving rise to negative uniphasic extracellular potentials, a notch might distort the registration of the rising phase of the action potential.

  4. 4.

    When the main direction of the depolarization wave is approaching the recording microelectrode, giving rise to positive uniphasic extracellular potentials,V max is transferred to less negative membrane potentials.

  5. 5.

    The extracellular surface electrogram influences the overshoot of the action potentials of the normal atrial and depressed (D-600) ventricular myocardium and is changed, depending on how the wave of excitation passes the recording microelectrode.

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Authors and Affiliations

  1. Institute of Zoophysiology, University of Lund, Helgonavägen 3b, S-22362, Lund, Sweden

    Per Arlock

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  1. Per Arlock
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The work was supported by grants from Hierta-Retzius fond för vetenskaplig forskning, Kungliga Fysiografiska Sällskapet, Lars Hiertas Minne, Magnus Bergvalls Stiftelse to Per Arlock and from Statens Naturvetenskapliga Forskningsråd to Anders Edström (NFR B 2535-017).

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Arlock, P. The influence of the surface electrogram on the rising phase of the mammalian cardiac action potential. Pflugers Arch. 380, 139–144 (1979). https://doi.org/10.1007/BF00582149

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  • DOI: https://doi.org/10.1007/BF00582149

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