Abstract
Moderate or severe hypertension was induced in rats by application of a clip 0.25 or 0.20 mm internal diameter) to the left renal artery leaving the contralateral kidney intact. Removal of the clip 6, 13 or 24 days after the induction of the hypertension was followed by a rapid decrease in blood pressure. A near normotensive level was reached after 2–6 h. Reapplication of the clip to the unclipped renal artery after 1 day caused an enhanced blood pressure response. The preoperative hypertensive levels were reached within 2 h. This enhanced response was related to the level of blood pressure before the removal of the clip. Lengthening the interval between removal and reapplication of the clip gradually reduced the enhanced response of blood pressure, which had disappeared 8 days after the removal of the clip. Reapplication of the clip to the contralateral renal artery was not followed by an enhanced response in rats with previous moderate or severe hypertension.
Similar content being viewed by others
References
Brown, J. J., Cuesta, V., Davis, D. L., Lever, A. F., Morton, J. J., Padfield, P. L., Robertson, J. I. S., Trust, P. Bianchi, G., Schalekamp, M. A. D.: Mechanism of renal hypertension. Lancet1976 II, 1219–1221
Davis, J. O.: The pathogenesis of chronic renovascular hypertension. Circ. Res.40, 439–444 (1977)
Deheneffe, J., Bernhard, A.: The pressor response to intravenously infused angiotensin II: Correlation with plasma renin activity. Clin. Sci. Mol. Med.46, 149–161 (1974)
De Jong, W.: Release of renin by rat kidney slices; relationship to plasma renin after desoxycorticosterone and renal hypertension. Proc. Soc. Exp. Biol. Med.130, 85–88 (1969)
Folkow, B., Hallbäck, M., Lundgren, Y., Weiss, L.: Time course and extent of structural adaptation of the resistance vessels in renal hypertensive (RHR) as compared with spontaneously hypertensive rats (SHR). Acta Physiol. Scand.87, 10A-11A (1973)
Gross, F., Brunner, H., Ziegler, M.: Renin-angiotensin system, aldosterone and sodium balance. Recent Prog. Horm. Res.21, 119–167 (1965)
Gulati, O. P., Carretero, O. A., Merino, T., Oza, M. B.: Urinary kallikerin and plasma renin during the reversal of renovascular hypertension in rats. Clin. Sci. Mol. Med.51, 263S-266S (1976)
Ichikawa, S., Johnson, J. A., Fowler, W. L., Payne, C. G., Kurz, K., Keitzer, F. W.: Pressor response to norepinephrine in rabbits with 3-day and 30-day renal artery stenosis. Circ. Res.43, 437–446 (1978)
Leenen, F. H. H., de Jong, W.: A solid silver clip for induction of predictable levels of renal hypertension in the rat. J. Appl. Physiol.31, 142–144 (1971)
Liard, J. F., Peters, G.: Role of the retention of water and sodium in two types of experimental renovascular hypertension in the rat. Pflügers Arch.344, 93–108 (1973)
Liard, J. F., Cowly, A. W., McCaa, R. E., McCaa, C. S., Guyton, A. C.: Renin, aldosterone, body fluid volumes, and the baroreceptor reflex in the development and reversal of Goldblatt hypertension in conscious dogs. Circ. Res.34, 549–560 (1974)
Lucas, J., Floyer, M. A.: Changes in body fluid distribution and intersitial tissue compliance during the development and reversal of experimental renal hypertension in the rat. Clin. Sci. Mol. Med.47, 1–11 (1974)
Lundgren, Y.: Regression of structural cardiovascular changes after reversal of experimental renal hypertension in rats. Acta Physiol. Scand.91, 275–285 (1974)
Lundgren, Y., Hallbäck, M., Weiss, L., Folkow, B.: Rate and extent of adaptive cardiovascular changes in rats during experimental renal hypertension. Acta Physiol. Scand.91, 103–115 (1974)
Muirhead, E. E., Leach, B. E., Byers, L. W., Pitcock, J. A.: Renomedullary interstitial cells and the antihypertensive renomedullary hormone. Clin. Res.24, 474A (1976)
Neubig, R. R., Hoobler, S. W.: Reversal of chronic renal hypertension: role of salt and water excretion. Proc. Soc. Exp. Biol. Med.150, 254–256 (1975)
Salgado, H. C., Krieger, E. M.: Reversibility of baroreceptor adaptation in chronic hypertension. Clin. Sci. Mol. Med.45, 123S-126S (1973)
Skulan, T. W., Brousseau, A. C., Leonard, K. A.: Accelerated induction of two kidney hypertension in rats and renin-angiotensin sensitivity. Circ. Res.35, 734–741 (1974)
Ten Berg, R. G. M., de Jong, W.: Plasma renin activity and sodium, potassium, water excretion during reversal of hypertension in one-clip two-kidney hypertensive rats. Clin. Sci. Mol. Med. (in press 1979)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ten Berg, R.G.M., de Jong, W. Time course of the enhanced blood pressure response to reinduction of renal artery stenosis in unclipped renal hypertensive rats. Pflugers Arch. 380, 133–137 (1979). https://doi.org/10.1007/BF00582148
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00582148