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Pflügers Archiv

, Volume 389, Issue 2, pp 131–135 | Cite as

Adaptive changes of juxtamedullary glomerular filtration in the remnant kidney

  • J. Phillip Pennell
  • Jacques J. Bourgoignie
Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands

Abstract

The participation of surviving juxtamedullary nephrons in the adaptive changes of glomerular filtration that occur in response to loss of functioning nephron mass was examined by direct micropuncture of the rat renal papilla. The solitary remnant kidney (RK) in rats with an 85% reduction of renal mass demonstrated strikingly elevated values for single nephron glomerular filtration rate (SNGFR) in both superficial (46.1±3.2 nl/min) and juxtamedullary (73.5±6.1 nl/min) nephrons in comparison to respective values observed in normal hydrophenic rats (superficial SNGFR=15.0±1.9nl/min,P<0.001, and juxtamedullary SNGFR=30.2±3.2 nl/min,P<0.001). In RK rats, the proximal portions of both superficial and juxtamedullary nephrons exhibited a marked increase in absolute fluid reabsorption as well as a markedly enhanced delivery of fluid to more distal portions of the nephron. These observations indicate that similar, not preferential, functional adaptations in glomerular filtration occur concommitantly in both superficial and juxtamedullary nephrons consequent to reduction of renal mass.

Key words

Juxtamedullary nephron Single nephron glomerular filtration rate Tubular reabsorption of fluid Remnant kidney model of uremia Micropuncture 

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References

  1. 1.
    Allison MEM, Lipham EM, Lassiter WE, Gottschalk CW (1973) The acutely reduced kidney. Kidney Int 3:354–363Google Scholar
  2. 2.
    Baines AO (1971) Effect of extracellular fluid volume expansion on maximum glucose reabsorbtion rate and glomerular tubular balance in single rat nephrons. J Clin Invest 50:2414–2425Google Scholar
  3. 3.
    Bank N, Aynedjian HS (1966) Individual nephron function in experimental bilateral pyelonephritis. Glomerular filtration rate and proximal tubular sodium potassium and water reabsorption. J Lab Clin Med 68:713–727Google Scholar
  4. 4.
    Bank N, Wie-Shing S, Aynedjian HS (1978) A micropuncture study of renal phosphate transport in rats with chronic renal failure and secondary hyperparathyroidism. J Clin Invest 61:884–894Google Scholar
  5. 5.
    Buerkert J, Head M, Klahr S (1977) Effects of bilateral ureteral obstruction on deep nephron and terminal collecting duct function in the young rat. J Clin Invest 59:1055–1065Google Scholar
  6. 6.
    Buerkert J, Martin D, Head M, Prasad J, Klahr S (1978) Deep nephron function after release of acute unilateral obstruction in the young rat. J Clin Invest 62:1228–1239Google Scholar
  7. 7.
    Buerkert J, Martin D, Prasad J, Chambless S, Klahr S (1979) Response of deep nephrons and the terminal collecting duct to a reduction in renal mass. Am J Physiol 236:F454-F464Google Scholar
  8. 8.
    Coelho JB, Chien KCH, Bradley SE (1972) Measurement of single-nephron glomerular filtration rate without micropuncture. Am J Physiol 223:832–839Google Scholar
  9. 9.
    de Rouffignac D, Deiss S, Bonvalet JP (1970) Determination du taux individuel de filtration glomerulaire des nephrons accessibles et inaccessibles a la micropunction. Pflügers Arch 315:273–290Google Scholar
  10. 10.
    de Rouffignac C, Bonvalet JP (1974) Structural and functional heterogeneity of mammalian nephrons. In: Thurau K (ed) Kidney and urinary tract physiology, vol 6. University Park Press. Baltimore, p. 391Google Scholar
  11. 11.
    Gilbert RM, Weber H, Turchin L, Fine LG, Bourgoignie JJ, Bricker NS (1976) A study of the intrarenal recycling of urea in the rat with chronic experimental pyelonephritis. J Clin Invest 58:1348–1357Google Scholar
  12. 12.
    Hayslett JP, Kashagarian M, Epstein FH (1968) Functional correlates of compensatory renal hypertrophy. J Clin Invest 47:774–782Google Scholar
  13. 13.
    Hayslett JP, Kashagarian M, Epstein FH (1969) Mechanisms of change in the excretion of sodium per nephron when renal mass is reduced. J Clin Invest 48:1002–1006Google Scholar
  14. 14.
    Horster M, Thurau K (1968) Micropuncture studies on the filtration rate of single superficial and juxtamedullary glomeruli in the rat kidney. Pflügers Arch 301:162–181Google Scholar
  15. 15.
    Imbut MJ, Berjal G, Moss M, de Rouffignac C, Bonvalet JP (1974) Number of nephrons in hypertrophic kidneys after unilateral nephrectomy in young adult rats. A functional study. Pflügers Arch 346:279–290Google Scholar
  16. 16.
    Jamison RL (1970) Micropuncture study of superficial and juxtamedullary nephrons in the rat. Am J Physiol 218:46–55Google Scholar
  17. 17.
    Jamison RL, Lacy FB (1971) Effect of saline infusion on superficial and juxtamedullary nephrons in the rat. Am J Physiol 221:690–697Google Scholar
  18. 18.
    Jamison RL, Buerkert J, Lacy FB (1973) A micropuncture study of Henle's thin loop in Brattleboro rats. Am J Physiol 224:180–185Google Scholar
  19. 19.
    Jamison RL (1973) Intrarenal heterogeneity. The case for two functionally dissimilar populations of nephrons in the mammalian kidney. Am J Med 54:281–289Google Scholar
  20. 20.
    Kaufman JM, DiMeola HJ, Siegel NJ, Lytton B, Kashagarian M, Hayslett JP (1974) Compensatory adaptation of structure and function following progressive renal ablation. Kidney Int 6:10–17Google Scholar
  21. 21.
    Kaufman JM, Siegel NM, Hayslett JP (1975) Functional and hemodynamic adaptations to progressive renal ablation. Circ Res 36:286–293Google Scholar
  22. 22.
    Kaufman JM, Hardy R, Hayslett JP (1976) Age-dependent characteristics of compensatory renal growth. Kidney Int 8:21–26Google Scholar
  23. 23.
    Lubowitz H, Purkerson ML, Sugita M, Bricker NS (1969) GFR per nephron and per kidney in chronically diseased (pyelonephritic) kidney of the rat. Am J Physiol 217:853–857Google Scholar
  24. 24.
    Pennell JP, Lacy FB, Jamison RL (1974) An in-vivo study of the concentrating process in the descending limb of Henle's loop. Kidney Int 5:337–347Google Scholar
  25. 25.
    Pennell JP, Sanjana V, Frey NR, Jamison RL (1975) The effect of urea infusion on the urinary concentrating mechanisms in protein-depleted rats. J Clin Invest 55:399–409Google Scholar
  26. 26.
    Purkerson ML, Hoffsten PE, Klahr S (1969) Pathogenesis of the glomerulopathy associated with renal infarction in rats. Kidney Int 9:406–417Google Scholar
  27. 27.
    Schultze RG, Shapiro HS, Bricker NS (1969) Studies on the control of sodium excretion in experimental uremia. J Clin Invest 48:869–877Google Scholar
  28. 28.
    Schutze RG, Weisser F, Bricker NS (1972) The influence of uremia on fractional sodium reabsorption by the proximal tubule of rats. Kidney Int 2:59–65Google Scholar
  29. 29.
    Snedecor GW (1956) Statistical methods. Iowa State University Press, AmesGoogle Scholar
  30. 30.
    Stumpe KO, Lowitz H, Ochwadt B (1969) Function of juxtamedullary nephrons in normotensive and chronically hypertensive rats. Pflügers Arch. 313:43–52Google Scholar
  31. 31.
    Valtin H (1977) Structural and functional heterogeneity of mammalian nephrons. Am J Physiol 233:F491-F501Google Scholar
  32. 32.
    Weber H, Lin K, Bricker NS (1975) Effect of sodium intake on single nephron glomerular filtration rate and sodium reabsorption in experimental uremia. Kidney Int 8:14–20Google Scholar
  33. 33.
    Wirz H, Spinelli F (1972) Recent advances in renal physiology. Karger, New YorkGoogle Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • J. Phillip Pennell
    • 1
  • Jacques J. Bourgoignie
    • 1
  1. 1.Department of Medicine, Division of NephrologyUniversity of Miami School of MedicineMiamiUSA

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