Pflügers Archiv

, Volume 389, Issue 2, pp 131–135 | Cite as

Adaptive changes of juxtamedullary glomerular filtration in the remnant kidney

  • J. Phillip Pennell
  • Jacques J. Bourgoignie
Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands


The participation of surviving juxtamedullary nephrons in the adaptive changes of glomerular filtration that occur in response to loss of functioning nephron mass was examined by direct micropuncture of the rat renal papilla. The solitary remnant kidney (RK) in rats with an 85% reduction of renal mass demonstrated strikingly elevated values for single nephron glomerular filtration rate (SNGFR) in both superficial (46.1±3.2 nl/min) and juxtamedullary (73.5±6.1 nl/min) nephrons in comparison to respective values observed in normal hydrophenic rats (superficial SNGFR=15.0±1.9nl/min,P<0.001, and juxtamedullary SNGFR=30.2±3.2 nl/min,P<0.001). In RK rats, the proximal portions of both superficial and juxtamedullary nephrons exhibited a marked increase in absolute fluid reabsorption as well as a markedly enhanced delivery of fluid to more distal portions of the nephron. These observations indicate that similar, not preferential, functional adaptations in glomerular filtration occur concommitantly in both superficial and juxtamedullary nephrons consequent to reduction of renal mass.

Key words

Juxtamedullary nephron Single nephron glomerular filtration rate Tubular reabsorption of fluid Remnant kidney model of uremia Micropuncture 


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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • J. Phillip Pennell
    • 1
  • Jacques J. Bourgoignie
    • 1
  1. 1.Department of Medicine, Division of NephrologyUniversity of Miami School of MedicineMiamiUSA

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