Classification of Na channel receptors specific for various scorpion toxins
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1. The specific binding to rat brain synaptosomes of a radiolabelled derivative of toxin II from the scorpionCentruroides suffusus suffusus could be prevented by toxins III and IV, but not by toxin V or variants 1–3, from the venom ofCentruroides sculpturatus.
2. The specific binding of a similar derivative of toxin II fromAndroctonus australis Hector was not affected by any of the toxins fromCentruroides sculpturatus.
3. There is biochemical evidence for only two distinct classes of Na channel receptors specific for known scorpion toxins.
Key wordsScorpion toxins Na channels specific receptors
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