Pflügers Archiv

, Volume 397, Issue 2, pp 164–165 | Cite as

Classification of Na channel receptors specific for various scorpion toxins

  • Kenneth P. Wheeler
  • Dean D. Watt
  • Michel Lazdunski
Excitable Tissues and Central Nervous Physiology Letters and Notes


1. The specific binding to rat brain synaptosomes of a radiolabelled derivative of toxin II from the scorpionCentruroides suffusus suffusus could be prevented by toxins III and IV, but not by toxin V or variants 1–3, from the venom ofCentruroides sculpturatus.

2. The specific binding of a similar derivative of toxin II fromAndroctonus australis Hector was not affected by any of the toxins fromCentruroides sculpturatus.

3. There is biochemical evidence for only two distinct classes of Na channel receptors specific for known scorpion toxins.

Key words

Scorpion toxins Na channels specific receptors 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Kenneth P. Wheeler
    • 1
  • Dean D. Watt
    • 2
  • Michel Lazdunski
    • 1
  1. 1.Centre de Biochimie du Centre National de la Recherche ScientifiqueUniversité de NiceNice CedexFrance
  2. 2.Department of BiochemistryCreighton UniversityOmahaUSA

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