Pflügers Archiv

, Volume 397, Issue 2, pp 160–163 | Cite as

Technique for producing heart block in closed-chest dogs without electrical recording

  • Bruce R. Ito
  • Eric O. Feigl
Heart, Circulation, Reapiration and Blood; Environmental and Exercise Physiology Instruments and Techniques

Abstract

An instrument and technique have been devised for the production of complete atrioventricular heart block in anesthetized, closed-chest animals. The instrument is inserted into the right atrium via the right external jugular vein. Localization of the atrioventricular node region by the visualization of intracardiac landmarks with fluoroscopy makes electrical recording unnecessary. Discrete injections of a radiopaque necrosing solution produces the heart block. Procedure time is under 30 min with a success rate of 90%.

Key words

Heart block Atrioventricular conduction Electrocardiogram Cardiac cannula 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Babotai I, Brownlee R (1971) Experimental atrioventricular block without thoracotomy: a new instrument. Cardiovasc Res 5:416–418Google Scholar
  2. Connolly CJ, Hannon DW, Edwards JE (1965) Experimental induction of chronic complete heart block. J Thorac Cardiovasc Surg 49:313–316Google Scholar
  3. Erlanger J, Blackman JR (1909–1910) Further studies in the physiology of heart block in mammals. Chronic auriculo-ventricular heart block in the dog. Heart 1:177–229Google Scholar
  4. Fisher VJ, Lee RJ, Christianson LC, Kavaler F (1966) Production of chronic atrioventricular block in dogs without thoracotomy. J Appl Physiol 21:1119–1121Google Scholar
  5. Gonzalez R, Scheinman M, Margaretten W, Rubinstein M (1981) Closed-chest electrode-catheter technique for His bundle ablation in dogs. Am J Physiol 241 (Heart Circ Physiol 10):H283-H287Google Scholar
  6. Goodale WT, Lubin M, Eckenhoff JE, Hafkenschiel JH, Banfield WG Jr (1948) Coronary sinus catheterization for studying coronary blood flow and myocardial metabolism. Am J Physiol 152:340–355Google Scholar
  7. Hashiba K, Katayama T, Takahashi A, Ono A, Matsuo S, Fujita J, Yamaguchi Y, Tazima N, Yoshioka M, Miura K (1965) Atrioventricular block produced by ligation of septal arteries in the dog. Jpn Heart J 6:256–267Google Scholar
  8. Pruett JK, Woods EF (1967) Technique for experimental complete heart block. J Appl Physiol 22:830–831Google Scholar
  9. Pruitt RD, Essex HE (1960) Potential changes attending the excitation process in the atrioventricular conduction system of bovine and canine hearts. Circ Res 8:149–174Google Scholar
  10. Randall OS, Westerhof N, Van den Bos GC, Sipkema P (1981) Production of chronic heart block in closed-chest dogs: an improved technique. Am J Physiol 241 (Heart Circ Physiol 10):H279-H282Google Scholar
  11. Shiang HC, Kupersmith J, Wiemann GF, Rhee C-Y, Litwak RS (1977) Creating permanent complete heart block by indirect cauterization without atriotomy. Am J Physiol 233:H723-H726Google Scholar
  12. Smyth NPD, Magassy CL (1970) Experimental heart block in the dog. An improved method. J Thorac Cardiovasc Surg 59:201–205Google Scholar
  13. Starzl TE, Gaertner RA, Baker RR (1955) Acute complete heart block in dogs. Circulation 12:82–89Google Scholar
  14. Steiner C, Kovalik ATW (1968) A simple technique for production of chronic complete heart block in dogs. J Appl Physiol 25:631–632Google Scholar
  15. Taufic M, Bashour FA, Lewis FJ (1955) Production of heart block in dogs under direct vision. Surg Forum 5:96–101Google Scholar
  16. Turina M, Babotai I, Wegmann W (1968) Production of chronic atrioventricular block in dogs without thoracotomy. Cardiovasc Res 4:389–393Google Scholar
  17. Wieberdink J (1966) Experimental production of permanent heart block (total or bundle branch block) without circulatory arrest or extracorporeal circulation. Thorax 21:401–404Google Scholar
  18. Williams JCP, Lambert EH (1964) Production of heart block in dogs without thoracotomy. (Abstract) Fed Proc 23:413Google Scholar
  19. Williams JCP, Lambert EH, Titus JL (1969) Use of intracardiac A-V nodal potentials in producing complete heart block in dogs. J Appl Physiol 27:740–744Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Bruce R. Ito
    • 1
  • Eric O. Feigl
    • 1
  1. 1.Department of Physiology and Biophysics SJ-40University of Washington School of MedicineSeattleUSA

Personalised recommendations