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Nucleotide-sensitive ion channels in human insulin producing tumour cells

  • Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands
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Abstract

Cells from a human insulin producing tumour have been studied and single channel currents recorded. We have observed three main cation-selective channels in excised patch experiments. An ATP-sensitive potassium channel is present the activity of which can be inhibited by the oral hypoglycaemic drug, tolbutamide. A calcium-activated nonselective cation channel, which is inhibited by AMP could also be seen. In addition a large conductance potassium selective channel, possibly the “maxi” calcium-activated potassium channel is present in these cells.

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Authors and Affiliations

  1. Department of Pharmacology, University of Cambridge, Hills Road, CB2 2QD, Cambridge, UK

    Nicholas C. Sturgess & Michael L. J. Ashford

  2. Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Hills Road, CB2 2QR, Cambridge, UK

    Christine A. Carrington & C. Nicholas Hales

Authors
  1. Nicholas C. Sturgess
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  2. Christine A. Carrington
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  3. C. Nicholas Hales
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  4. Michael L. J. Ashford
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Sturgess, N.C., Carrington, C.A., Hales, C.N. et al. Nucleotide-sensitive ion channels in human insulin producing tumour cells. Pflugers Arch. 410, 169–172 (1987). https://doi.org/10.1007/BF00581911

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  • DOI: https://doi.org/10.1007/BF00581911

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