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On the regulation of the renal response to blood volume expansion by vascular parameters in the rat

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Summary

  1. 1.

    The dynamic patterns of body fluid volume distribution, of cardiovascular variables and of renal water, sodium and potassium excretion were studied in the anaesthetized rat following acute, iso-oncotic blood volume expansion.

  2. 2.

    The increased renal excretion following expansion was soon reversed and its pattern to termination was not correlated with changes in pulse and mean arterial pressure, in plasma electrolyte concentration or in haematocrit.

  3. 3.

    At the end of the renal response the change in extracellular fluid volume was not usually corrected, the blood volume was always well above its control value and the interstitial fluid was below its control value.

  4. 4.

    In all cases the temporal pattern and the termination of the renal response corresponded closely with the temporal pattern and the return to the control value of the central venous mean and pulse pressure.

  5. 5.

    The findings of these experiments are not consistent with the view that any of the measured body fluid volumes directly and always determine renal excretion.

  6. 6.

    It is proposed that in response to an acute blood volume expansion an animal may initially regulate neither its blood volume nor its extracellular fluid volume but rather a factor which is reflected in or related to the central venous pressure.

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References

  1. Ackermann, U.: An approach to the measurement of body fluid compartment volumes in non-steady state conditions in the rat. Pflügers Arch.355, 141–150 (1975)

    Google Scholar 

  2. Bank, N.: The renal regulation of sodium transport. Bull. N. Y. Acad. Med.46, 818–829 (1970)

    Google Scholar 

  3. Brenner, B. M., Galla, J. H.: Influence of postglomerular hematocrit and protein concentration on rat nephron fluid transfer. Amer. J. Physiol.220, 148–161 (1971)

    Google Scholar 

  4. Gauer, O. H., Henry, J. P., Behn, C.: The regulation of extracellular fluid volume. Ann. Rev. Physiol.32, 547–595 (1970)

    Google Scholar 

  5. Gauer, O. H. Henry, J. P., Sieker, H. O.: Cardiac receptors and fluid volume control. Progr. cardiovasc. Dis.4, 1–26 (1961)

    Google Scholar 

  6. Gilmore, J. P.: Contribution of cardiac nerves to the control of body salt and water. Fed. Proc.27, 1156–1159 (1968)

    Google Scholar 

  7. Goetz, K. L., Hermreck, G. I., Slick, G. L., Starke, H. S.: Atrial receptors and renal function in conscious dogs. Amer. J. Physiol.219, 1417–1423 (1970)

    Google Scholar 

  8. Greenberg, T. T., Richmond, W. H., Stocking, R. A., Gupta, P. D., Meehan, J. P., Henry, J. P.: Impaired atrial receptor responses in dogs with heart failure due to tricuspid insufficiency and pulmonary artery stenosis. Circulat. Res.32, 424–433 (1973)

    Google Scholar 

  9. Gupta, P. D., Henry, J. P., Sinclair, R., von Baumgarten, R.: Responses of atrial and aortic baroreceptors to non-hypotensive haemorrhage and to transfusion. Amer. J. Physiol.211 1429–1437 (1966)

    Google Scholar 

  10. Guyton, A. C.: Interstitial fluid pressure. II. Pressure-volume curves of interstitial space. Circulat. Res.16, 452–460 (1965)

    Google Scholar 

  11. Hayter, C. J., Clapham, W. F., Mills, I. H., deWardener, H. E.: Red blood cells and plasma ‘disappearance’ during rapid plasma volume expansion. Clin. Sci.23, 229–236 (1962)

    Google Scholar 

  12. Henry, J. P., Pearce, J. W.: The possible role of cardiac atrial stretch receptors in the induction of changes in urine flow. J. Physiol. (Lond.)131, 572–585 (1956)

    Google Scholar 

  13. Houttuin, E., Bengele, H. H., Pearce, J. W.: Effect of altered initial hematocrit on the renal response to blood volume expansion. Amer. J. Physiol.223, 63–67 (1972)

    Google Scholar 

  14. Johnson, B. B., Lieberman, A. H., Mulrow, P. J.: Aldosterone excretion in normal subjects depleted of sodium and potassium. J. clin. Invest.36, 757–766 (1957)

    Google Scholar 

  15. Johnson, J. A., Moore, W. W., Segar, W. E.: Small changes in left atrial pressure and plasma antidiuretic hormone titers in dogs. Amer. J. Physiol.217, 210–214 (1969)

    Google Scholar 

  16. Kaiser, D., Linkenbach, H. J., Gauer, O. H.: Änderung des Plasmavolumens des Menschen bei Immersion in ein thermoindifferentes Wasserbad. Pflügers Arch.308, 166–173 (1969)

    Google Scholar 

  17. Keck, W., Joppich, R., v. Restorff, W. D., Finsterer, U., Prucksunand, P., Brechtelsbauer, H., Kramer, K.: Sodium excretion in conscious and anesthetized dogs after large saline infusions. Pflügers Arch.341, 51–62 (1973)

    Google Scholar 

  18. Lauson, H. D.: Metabolism of antidiuretic hormones. Amer. J. Med.42, 713–744 (1967)

    Google Scholar 

  19. Ledsome, J. R., Linden, R. J.: The role of left atrial receptors in the diuretic response to left atrial distension. J. Physiol. (Lond.)198, 487–503 (1968)

    Google Scholar 

  20. Nizet, A.: Control by plasma potassium concentration of sodium excretion by isolated perfused dog kidney. Pflügers Arch. ges. Physiol.297, 162–165 (1967)

    Google Scholar 

  21. Osler, B. L.: Hawk's Physiological Chemistry, 14th edit., p. 1085. Philadelphia: Blakiston 1965

    Google Scholar 

  22. Pearce, J. W.: Blood volume regulation and the dynamics of the low pressure vascular system. Proc. Int. U. Physiol. Soc. (XXV Int. Cong., Munich), vol.8, pp. 81–82 (1971)

    Google Scholar 

  23. Porciuncula, C. J., Armstrong, G. G., Guyton, A. C., Stone, H. K.: Delayed compliance in external jugular vein of the dog. Amer. J. Physiol.207, 728–732 (1964)

    Google Scholar 

  24. Prather, J. W., Taylor, A. E., Guyton, A. C.: Effect of blood volume, mean circulatory pressure and stress relaxation on cardiac output. Amer. J. Physiol.216, 467–472 (1969)

    Google Scholar 

  25. Schrier, R. W., McDonald, K. M., Marshall, R. A., Lauler, D. P.: Absence of natriuretic response to acute hypotonic intravascular volume expansion in dogs. Clin. Sci.34, 57–72 (1968)

    Google Scholar 

  26. Share, L., Levy, M. N.: Cardiovascular receptors and blood titer of ADH. Amer. J. Physiol.203, 425–428 (1962)

    Google Scholar 

  27. Share, L., Levy, M. N.: Carotid sinus pulse pressure, a determinant of plasma antidiuretic hormone concentration. Amer. J. Physiol.211, 721–724 (1966)

    Google Scholar 

  28. Snedecor, G. W., Cochran, W. G.: Statistical Methods, 6th edit., p. 432. Ames: Iowa State University Press 1967

    Google Scholar 

  29. Sonnenberg, H., Pearce, J. W.: Renal response to measured blood volume expansion in differently hydrated dogs. Amer. J. Physiol.203, 344–352 (1962)

    Google Scholar 

  30. Sonnenberg, H., Veress, A. T., Pearce, J. W.: A humoral component of the natriuretic mechanism in sustained blood volume expansion. J. clin. Invest.51, 2631–2644 (1972)

    Google Scholar 

  31. Thurau, K., Deetjen, P.: Die Diurese bei arteriellen Drucksteigerungen. Pflügers Arch. ges. Physiol.274, 567–580 (1962)

    Google Scholar 

  32. Veress, A. T., Pearce, J. W.: Effect of vagotomy on the renal response to blood volume expansion in the rat. Canad. J. Physiol. Pharmacol.50, 463–466 (1972)

    Google Scholar 

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Authors and Affiliations

  1. Department of Physiology and Institute of Bio-Medical Electronics and Engineering, University of Toronto, Canada

    U. Ackermann

  2. Faculty of Medicine, Memorial University of Newfoundland, A1C 5S7, St. John's, Newfoundland, Canada

    U. Ackermann

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  1. U. Ackermann
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This study was supported by the Medical Research Council of Canada.

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Ackermann, U. On the regulation of the renal response to blood volume expansion by vascular parameters in the rat. Pflugers Arch. 355, 151–164 (1975). https://doi.org/10.1007/BF00581830

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  • DOI: https://doi.org/10.1007/BF00581830

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