Conclusions
The methods required to demonstrate that a particular food additive is safe for human consumption depend on the compound involved and on the specific use of the material. In other words, each additive presents a specific and a different problem. Therefore, the toxicological investigation required may range anywhere from a few simple tests to a most comprehensive and time consuming investigation. A most important factor in each of these studies is the investigator himself. There is no simple formula, and certainly no substitute for the mature and considered judgement of the man who by experience and training is qualified to interpret the experimental data.
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Lehman, A. J., W. I. Patterson, B. Davidow, E. C. Hagen, G. Woodard, E. P. Laug, J. P. Frawley, O. G. Fitzhugh, A. R. Bourke, J. H. Draize, A. A. Nelson andB. J. Vos: Procedures for the appraisal of the toxicity of chemicals in foods, drugs and cosmetics. Food. Drug cosmetic. Law J., Vol. 17, No. 10, 579–720 (1962).
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Dr.William B.Deichmann has restated here quite correctly the requirements established by the F. D. A. for the toxicological testing of food additives.Arnold J.Lehman, M. D. (Director, Pharmacology Division, Food and Drug Administration, U. S. Department of Health, Education, and Welfare, Washington, D.C., U.S.A.).
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Deichmann, W.B. F.D.A. Requirements for food additives in the U.S.A.. Archiv für Toxikologie 20, 1–11 (1963). https://doi.org/10.1007/BF00581733
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DOI: https://doi.org/10.1007/BF00581733