Pflügers Archiv

, Volume 370, Issue 2, pp 201–209 | Cite as

Local oxygen tension and spike activity of the cerebral grey matter of the rat and its response to short intervals of O2 deficiency or CO2 excess

  • Hermann Metzger
  • Sabine Heuber
Article

Summary

Local\(P_{ O_2 }\) differences within the rat brain cortex were analyzed with an O2 microsensor slowly advanced from the brain surface into the deep cortical structures. The\(P_{ O_2 }\) tended to decrease from the pia (40 mm Hg) to the deep cortex (4 mm Hg). The mean tissue\(P_{ O_2 }\) of the occipital cortex of 21 rats (5229 measuring points) was found to be 14 mm Hg; great local variations indicate a very inhomogeneous capillary-tissue system.

\(P_{ O_2 }\) time variations and extracellular action potentials registered from the same brain portion were investigated applying short pulses of inspiratory N2 and CO2. During pronounced hypoxia and hypercapnia the number of spikes per second deceased rapidly, whereas an increased spike activity was observed during slight hypercapnia. For the posthypoxic and posthypercapnic periods, the time course of the local\(P_{ O_2 }\), may be mathematically described by means of a second-order delay term with a proportional differential component. A comparison of these results shows that the response after hypercapnia is much faster than after hypoxia. The fact that cortical cells show the same reactions to hypoxia and hypercapnia as spinal cells, argues against a specific O2 receptor in the brain itself.

Key words

Local\(P_{ O_2 }\) in the rat brain cortex Local\(P_{ O_2 }\) and APs Transient hypoxia and hypercapnia \(P_{ O_2 }\) regulation 

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Hermann Metzger
    • 1
  • Sabine Heuber
    • 1
  1. 1.Physiologisches InstitutMedizinische Hochschule HannoverHannover 61Federal Republic of Germany

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