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Some electron microscopic and autoradiographic results concerning cutaneous neurofibromas in von recklinghausen's disease

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Summary

The cutaneous tumors of 5 patients with clinical symptoms of Recklinghausens neurofibromatosis were investigated by light and electron microscopy. Special reference was given to the study of initial changes of the disease and the structure of the nerve fascicles which end in the tumor. In 2 patients the proliferating cells were determined by using an antoradiographic technique. It was discovered that all cellular elements of a peripheral nerve are involved by the tumor formation. The results were discussed and compared with the alterations during nerve regeneration after traumatic injury.

Zusammenfassung

Die Hautknoten von 5 Patienten mit klinisch diagnostizierter Neurofibromatose Recklinghausen wurden im Hinblick auf die initialen Veränderungen der Erkrankung licht- und elektronenmikroskopisch untersucht. Besonderes Augenmerk wurde auf die Struktur der Nervenfaszikel, die für die Bildung der Tumore verantwortlich sind, gerichtet. Bei 2 Patienten wurden mit Hilfe autoradiographischer Methoden die proliferierenden Zellen bestimmt. Die Untersuchungen ergaben, daß bei der Tumorbildung alle Zelltypen des peripheren Nerven beteiligt sind: Die Schwannschen Zellen, die Endoneuralfibroblasten und die Perineuralzellen. Die Veränderungen wurden mit dem normalen Ablauf der Nervenregeneration nach traumatischer Schädigung verglichen.

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Authors and Affiliations

  1. Institut für Mikromorphologie und Elektronenmikroskopie, Universität und II. Universitäts-Hautklinik, Vienna, Austria

    H. Lassmann, W. Jurecka & W. Gebhart

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  1. H. Lassmann
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  2. W. Jurecka
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  3. W. Gebhart
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Lassmann, H., Jurecka, W. & Gebhart, W. Some electron microscopic and autoradiographic results concerning cutaneous neurofibromas in von recklinghausen's disease. Arch. Derm. Res. 255, 69–81 (1976). https://doi.org/10.1007/BF00581680

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