Chemistry of Natural Compounds

, Volume 18, Issue 1, pp 90–94 | Cite as

Use of pentafluorophenyl esters in the synthesis of intermediate fragments of ACTH

  • V. N. Karel'skii
  • E. P. Krysin
  • A. A. Antonov
  • G. E. Rostovskaya
Article
  • 79 Downloads

Abstract

The results are given of the synthesis of the heptapeptide 13–19 of the natural sequence of ACTH using, in a number of stages, the pentafluorophyl esters of amino acids and peptides in combination with the temporary silyl protection of the carboxy group of the amino components. The intermediate compounds were obtained with good yields (70–90%) in chromatographically homogeneous form and their physicochemical characteristics did not differ from those of similar products obtained by other methods and described in the literature. The identification and checking of the purity of the compounds synthesized was carried out not only by traditional methods but also by the13C NMR method and by high-pressure liquid chromatography. Some physicochemical characteristics of the compounds synthesized are given.

Keywords

Carboxy Group DMFA Natural Sequence Methyl Chloride Ethyl Chloroformate 

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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • V. N. Karel'skii
  • E. P. Krysin
  • A. A. Antonov
  • G. E. Rostovskaya

There are no affiliations available

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