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Pflügers Archiv

, Volume 376, Issue 2, pp 177–184 | Cite as

Psychomotor behaviour and cardiovascular patterns during stimulation of the amygdala

  • G. Stock
  • K. H. Schlör
  • H. Heidt
  • J. Buss
Heart, Circulation, Respiration and Blood; Environmental and Exercise Physiology

Abstract

  1. 1.

    Stimulation within the amygdaloid complex elicited two different behavioural and cardiovascular patterns of response. In the awake animal stimulation of the magnocellular part of the basal amygdala resulted in a defence reaction. Stimulation parameters eliciting only the first stage of this behaviour induced a moderate tachycardia and a shortlasting decrease in arterial pressure followed by an increase. Aortic blood flow measured distal to the renal arteries was increased; hence calculated peripheral vascular resistance was decreased. The increase in blood flow was blocked by both atropine sulphate and methyl-atropine.

     
  2. 2.

    Stimulation of the central amygdala in the awake cat elicited a behaviour which was different from a typical defence reaction. The response appeared to be more similar to attack or a superimposition of attack on the defence reaction. Stimulation of this area with lower stimulus intensities elicited a cardiovascular pattern consisting of tachycardia, which was sensitive to β-blockade, increased arterial pressure, which remained elevated for the entire period of stimulation and increased calculated peripheral resistance. These latter changes were blocked by application of phenoxybenzamine as well as of phentolamine. Moreover, there was a marked post-stimulation bradycardia, which was abolished by application of atropine sulphate.

     
  3. 3.

    Intravenous administration of sodium pentobarbitone did not alter the cardiovascular patterns induced by stimulation of the central or basal amygdala if the dose of pentobarbitone did not exceed 25 mg/kg. However, stimulus intensities had to be increased by a factor of 2 to 3 in order to elicit comparable cardiovascular responses. If the dose of pentobarbitone exceeded 25 mg/kg, the well-defined cardiovascular patterns elicited by stimulation of the two different amygdaloid nuclei could not be observed. In contrast, stimulation of sites within the ventromedial hypothalamus, performed in the same animal, showed that the cardiovascular responses could be elicited also after application of 40–45mg/kg of pentobarbitone. Hence it is concluded that anaesthetic agents such as pentobarbitone act largely on neuronal elements between the amygdala and hypothalamus.

     

Key words

Amygdala Anaesthesia Vasoconstriction Vasodilatation Psychomotor behaviour 

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References

  1. Abrahams, V. C., Hilton, S. M., Zbrožyna, A. W.: Active muscle vasodilatation produced by stimulation of the brain stem: its significance in the defence reaction. J. Physiol. (Lond.)154, 491–513 (1960)Google Scholar
  2. Anand, B. K., Dua, S.: Circulatory and respiratory changes induced by electrical stimulation of the limbic system (visceral brain). J. Neurophysiol.19, 393–400 (1956)Google Scholar
  3. Andén, N.-E., Strömbom, U.: Adrenergic receptor blocking agents: effects on central noradrenaline and dopomine receptors and on motor activity. Psychopharmacologia (Berl.)38, 91–103 (1974)Google Scholar
  4. von Baumgarten, R., Kanzow, E., Koepchen, H. P., Timm, F.: Beitrag zur Technik der extra- und intracellulären, sowie der stereotaktischen Mikroableitung im Gehirn. Pflügers Arch. ges. Physiol.271, 245–256 (1960)Google Scholar
  5. Djojosugito, A. M., Folkow, B., Lisander, B., Sparks, H.: Mechanism of escape of skeletal muscle resistance vessels from the influence of sympathetic cholinergic vasodilator fibre activity. Acta Physiol. Scand.72, 148–156 (1968)Google Scholar
  6. Edvinsson, L., Nielsen, K. C., Owman, Ch., West, K. A.: Alteration in intracranial pressure, blood-brain barrier, and brain edema after sub-chronic implantation of a cannula into the brain of conscious animals. Acta Physiol. Scand.82, 527–531 (1971)Google Scholar
  7. Forsyth, R. P., Hoffbrand, B. L.: Redistribution of cardiac output after sodium pentobarbital anaesthesia in the monkey. Am. J. Physiol.218, 214–217 (1970)Google Scholar
  8. Heinemann, H., Stock, G., Schaefer, H.: Temporal correlation of responses in blood pressure and motor reaction under electrical stimulation of limbic structures in unanaesthetized, unrestrained cats. Pflügers Arch.343, 27–40 (1973)Google Scholar
  9. Herz, A., Teschemacher, H., Hofstetter, A., Kurz, H.: The importance of lipid-solubility for the central action of cholinolytic drugs. Int. J. Neuropharmacol.4, 207–218 (1965)Google Scholar
  10. Hilton, S. M.: Ways of viewing the central nervous control of the circulation — old and new. Brain Res.87, 213–219 (1975)Google Scholar
  11. Hilton, S. M., Zbrožyna, A. W.: Defence reaction from the amygdala and its afferent and efferent connections. J. Physiol. (Lond.)165, 160–173 (1963)Google Scholar
  12. Kaada, B. R.: Somatomotor, autonomic and electrocorticographic responses to electrical stimulation of ‘rhinencephalic’ and other structures in primates, cat and dog. Acta Physiol. Scand.24, Suppl. 83, 1–285 (1951)Google Scholar
  13. Kaada, B. R.: Stimulation and regional ablation of the amygdaloid complex with reference to functional representation. In: The neurobiology of the amygdala. Advances in behavioural biology, Vol. 2 (B. D. Eleftheriou, ed.), pp. 105–281. New York-London: Plenum Press 1972Google Scholar
  14. Klüver, H., Barrera, E.: A method for the combined staining of cells and fibres in the nervous system. J. Neuropath. exp. Neurol.12, 400–403 (1953)Google Scholar
  15. Klüver, H., Bucy, P. C.: “Psychic blindness” and other symptoms following bilateral lobectomy in rhesus monkeys. Am. J. Physiol.119, 352–353 (1937)Google Scholar
  16. Koikegami, H., Kimoto, A., Kido, C.: Studies on the amygdaloid nuclei and periamygdaloid cortex. Experiments on the influence of their stimulation upon motility of small intestine and blood pressure. Folia Psychiat. Neurol. Jap.7, 87–108 (1953)Google Scholar
  17. Leyhausen, P.: Verhaltensstudien an Katzen. Berlin-Hamburg: Parey 1973Google Scholar
  18. MacLean, P. D.: Psychosomatic disease and the “visceral brain”. Psychosom. Med.11, 338–353 (1949)Google Scholar
  19. MacLean, P. D.: Some psychiatric implications of physiological studies on fronto-temporal portion of limbic system (visceral brain). Electroencephalogr. Clin. Neurophysiol.4, 407–418 (1952)Google Scholar
  20. MacLean, P. D.: Contrasting functions of limbic and neocortical systems of the brain and their relevance to psychophysiological aspects of medicine. Am. J. Med.25, 611–626 (1958)Google Scholar
  21. Mogenson, G. J., Calaresu, F. R.: Cardiovascular responses to electrical stimulation of the amygdala in the rat. Exp. Neurol.39, 166–180 (1973)Google Scholar
  22. Morin, G., Naquet, R., Badier, M.: Stimulation électrique de la région amygdalienne et pression artérielle chez le chat. J. Physiol. (Paris)44, 303–305 (1952)Google Scholar
  23. Price, H. L.: General anaesthesia and circulatory homeostasis. Physiol. Rev.40, 187–218 (1960)Google Scholar
  24. Reinoso-Suarez, F.: Topographischer Hirnatlas der Katze für experimental-physiologische Untersuchungen. Darmstadt: E. Merck AG 1961Google Scholar
  25. Schlör, K. H., Heidt, H., Buss, J., Stock, G.: The influence of the amygdaloid complex on cardiovascular parameters. Pflügers Arch.395, R73 (1975)Google Scholar
  26. Timms, R. J.: The use of anaesthetic steroids alphaxalone-alphadalone in studies of the forebrain in the cat. J. Physiol. (Lond.)256, 71P-72P (1976)Google Scholar
  27. Torii, S., Kawamura, H.: Effects of amygdaloid stimulation on blood pressure and electrical activity of the hippocampus. Jap. J. Physiol.10, 374–384 (1960)Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • G. Stock
    • 1
  • K. H. Schlör
    • 1
  • H. Heidt
    • 1
  • J. Buss
    • 1
  1. 1.Physiologisches Institut der Universität HeidelbergHeidelbergFederal Republic of Germany

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