Pflügers Archiv

, Volume 404, Issue 1, pp 61–66 | Cite as

Water handling by the sabra hypertension prone (SBH) and resistant (SBN) rats

  • Yoram Yagil
  • Drori Ben-Ishay
  • Hanna Wald
  • Mordechai M. Popovtzer
Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands


The renal handling of water by SBH and SBN rats was evaluated under basal conditions and following various intervention procedures. During 17 weeks of unrestricted water intake, SBH rats drank less water and excreted less urine with a higher osmolality than SBN. The differences in urine volume and osmolality persisted during 2 weeks of paired water intake. Acute water loading elicited comparable dilution of the urine in the two strains. Water deprivation for 48 h resulted in a marked rise in urine osmolality, which tended to be higher in SBN. Administration of exogenous vasopressin in water loaded animals caused a similar rise in urine osmolality. Papillary solute and urea content was higher in SBH than in SBN, but comparable in water loaded animals. The results show that although SBH differ from SBN rats in the handling of water under basal conditions, their renal diluting and concentrating capacity is comparable at extreme conditions. GFR and RBF were equal in both strains. The data suggest that SBH rats have increased renal water reabsorption as compared to SBN, which may be mediated by ADH, PG or other mechanisms. This characteristic may be related to their propensity to develop hypertension.

Key words

Genetic hypertension Rats Water handling Anti-diuretic hormone 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Beck TR, Dunn MJ (1981) The relationship of anti-diuretic hormone and renal prostaglandins. Miner Elec Metab 6:46–59Google Scholar
  2. 2.
    Beierwaltes WH, Arendshorst WJ, Klemmer PJ (1982) Electrolyte and water balance in young spontaneously hypertensive rats. Hypertension 4:908–915Google Scholar
  3. 3.
    Ben Ishay D, Saliternik R, Welner A (1972) Separation of two strains of rats with inbred dissimilar sensitivity to DOCA Salt hypertension. Experientia 28:1321Google Scholar
  4. 4.
    Ben Ishay D, Zamir N, Feuerstein G, Kobrin I, Le Quan Bui KL, Devynck MA (1981) Distinguishing traints in the Sabra hypertension prone (SBH) and hypertension resistant (SBN) rats. Clin Exp Hypertens 3:737–747Google Scholar
  5. 5.
    Bianchi G, Fox U, Di Franceso GF, Giovanneti AM, Pagetti D (1974) Blood pressure changes produced by kidney cross transplantation between spontaneously hypertensive rats (SHR) and normotensive rats (NR) Clin Sci Mol Med 47:435–448Google Scholar
  6. 6.
    Coleman TG, Guyton AC, Young DB, De Clue JW, Norman RAJ, Manning RD Jr (1975) The role of the kidney in essential hypertension. Clin Exp Pharmacol Physiol 2:571–581Google Scholar
  7. 7.
    Dahl LK, Heine M, Thompson K (1974) Genetic influence of the kidneys on blood pressure. Evidence from chronic renal homorafts in rats with opposite predispositions to hypertension. Circulat Res 34:94–101Google Scholar
  8. 8.
    Feuerstein G, Zerbe RL, Ben Ishay D, Kopin IJ, Jacobowitz DM (1981) Carecholamines and vasopressin in forebrain nuclei of hypertension prone and resistant rats. Brain Res Bull 7:671–676Google Scholar
  9. 9.
    Guyton AC, Coleman TG, Cowley AW, Scheel KW, Manning RDJ, Norman RA Jr (1972) Arterial pressure regulation. Overriding dominance of the kidneys in long term regulation and in hypertension. Am J Med 52:584–594Google Scholar
  10. 10.
    Kaplan NM (1983) Renal dysfunction in essential hypertension. NEJM 309:1052Google Scholar
  11. 11.
    Kawabe K, Watanabe T, Shiono K, Sokabe H (1978) Influence on blood pressure of renal isografts between spontaneously hypertensive and normotensive rats, using the F1 hybrids. Jpn Heart J 19:886–894Google Scholar
  12. 12.
    Levitin H, Goodman A, Pigeon G, Epstein FH (1962) Composition of the renal medulla during water diuresis. J Clin Invest 41:1145–1151Google Scholar
  13. 13.
    Popovtzer MM, Robinette JB, Halgrimson CG, Stanze TE (1974) Acute effect of prednisolone on renal handling of sodium: Evidence for direct natriuretic action. Am J Physiol 224:651–658Google Scholar
  14. 14.
    Share L, Crofton JT (1982) Contribution of vasopressin to hypertension. Hypertension 4 (Suppl III):85–92Google Scholar
  15. 15.
    Shorer D, Weinstock M, Ben-Ishay D (1982) Increased baroreceptor sensitivity in hypertension resistant Sabra rats. In: Rascher W, Clough D, Ganten D (eds) Hypertensive mechanisms. FK Schattauer, Stuttgart New York, pp 371–374Google Scholar
  16. 16.
    Smith HW, Finkelstein N, Aliminosa L, Crowford B, Graber N (1945) Renal clearances of substituted hippuric acid derivatives and other aromate acid derivatives in dog and man. J Clin Invest 24:388Google Scholar
  17. 17.
    Yazaki Y, Ohuchi Y, Ashida T, Saito T (1981) The importance of vasopressin in the mechanism maintaining hypertension in the rat. Jpn Circul J 45:1116–1120Google Scholar
  18. 18.
    Witzman R, Kleeman CR (1980) Water metabolism and the neurohypophyseal hormones. In: Maxwell MH, Kleeman CR (eds) Clinical disorders of fluid and electrolyte metabolism. McGraw-Hill Book Company, New York, pp 531–645Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Yoram Yagil
    • 2
    • 1
  • Drori Ben-Ishay
    • 2
    • 1
  • Hanna Wald
    • 2
    • 1
  • Mordechai M. Popovtzer
    • 2
    • 1
  1. 1.Nephrology ServicesHadassah University HospitalJerusalemIsrael
  2. 2.Hypertension Unit, Department of MedicineHadassah University HospitalJerusalemIsrael

Personalised recommendations