Abstract
The effect of microtubular-poisons, such as colchicine and vincristine, on frog skin permeability has been investigated. Three-hour treatment with the drugs has no effect on nonelectrolyte basal transepithelial permeability, but completely supresses the effect of ADH. Colchicine and vincristine, in addition, affect both basal sodium transport and the rise in short circuit current induced by vasopressin.
The inhibition produced by microtubular-poisons disappears, however, when hydrocortisone, a glucocorticoid known to preserve junctional communications is used.
Together with the results previously obtained with isolated epithelial cells (Svelto et al. 1979), these findings provide further support for our hypothesis that the microtubularmicrofilament-system, is involved in cell-to-cell exchange.
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Svelto, M., Casavola, V. Protective effect of hydrocortisone on vasopressin response in frog skin. Pflugers Arch. 392, 152–156 (1981). https://doi.org/10.1007/BF00581264
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DOI: https://doi.org/10.1007/BF00581264