Pflügers Archiv

, Volume 404, Issue 3, pp 290–291 | Cite as

Naloxone does not influence a pyrogen fever in rabbits

  • R. F. Hellon
  • Y. Townsend
  • W. I. Cranston
Heart, Circulation, Respiration and Blood; Environmental and Exercise Physiology Short Communication


Rabbits were made febrile by an intravenous injection of homologous endogenous pyrogen (Interleukin 1). When naloxone (0.1 mg/kg i.v.) followed by 0.06 mg (kg·hr)−1 infusion) was given at the same time as the pyrogen, the resulting fever was indistinguishable from that following pyrogen alone. It appears unlikely that opioid receptors which are blocked by naloxone play any important part in the fever process.

Key words

Fever β-endorphin naloxone 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • R. F. Hellon
    • 1
  • Y. Townsend
    • 2
  • W. I. Cranston
    • 2
  1. 1.National Institute for Medical ResearchLondonUK
  2. 2.Department of MedicineSt. Thomas's Hospital Medical SchoolLondonUK

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