Skip to main content
SpringerLink
Log in

Evidence for the involvement of adenosine 3′,5′-cyclic monophosphate in fever genesis

  • Published:
Pflügers Archiv Aims and scope Submit manuscript

Summary

In rabbit cerebrospinal fluid (CSF) during fever induced by endotoxins, myxoviruses, or endogenous pyrogen, concentrations of adenosine 3′,5′-cyclic monophosphate (cyclic AMP) and prostaglandin E (PGE) are about 2-fold higher in comparison to normal values. In endotoxin treated animals paracetamol reduced the fever reaction and both PGE and cyclic AMP levels. Administration of theophyllin together with endotoxin enhanced the fever reaction and cyclic AMP levels in CSF, but had no influence on stimulation of PGE synthesis. Following injection of PGE2 into the lateral cerebral ventricles increased cyclic AMP concentrations were found in CSF. The results suggest, that the pyrogenic effect of PGE is mediated by stimulation of cerebral cyclic AMP synthesis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bloom, F. E., Siggins, G. R., Hoffer, B. J.: Interpreting the failures to confirm the depression of cerebellar Purkinje cells by cyclic AMP. Science185, 627–629 (1974)

    Google Scholar 

  2. Breckenridge, B. McL., Lisk, R. D.: Cyclic adenylate and hypothalamic regulatory functions. Proc. Soc. exp. Biol. (N. Y.)131, 934–935 (1969)

    Google Scholar 

  3. Clark, W. G., Cumby, H. R., Davis, H. E. IV: The hyperthermic effect of intracerebroventricular cholera enterotoxin in the unaesthetized cat. J. Physiol. (Lond.)240, 493–504 (1974)

    Google Scholar 

  4. Cramer, H., Ng, L. K. Y., Chase, T. N.: Effect of probenecid on levels of cyclic AMP in human cerebrospinal fluid. J. Neurochem.19, 1601–1602 (1972)

    Google Scholar 

  5. Dey, P. K., Feldberg, W., Wendlandt, S.: Lipid A and prostaglandin. J. Physiol. (Lond.)239, 102P-103P (1974)

    Google Scholar 

  6. Doggett, N. S., Spencer, P. S. J.: Pharmacological properties of centrally administered agents which interfere with neurotransmitter function: a comparison with the central depressant effects of ouabain. Brit. J. Pharmacol.47, 26–38 (1973)

    Google Scholar 

  7. Feldberg, W., Gupta, K. P.: Pyrogen fever and prostaglandinlike activity in crebrospinal fluid. J. Physiol. (Lond.)228, 41–53 (1973)

    Google Scholar 

  8. Feldberg, W., Gupta, K. P., Milton, A. S., Wendlandt, S.: Effect of pyrogen and antipyretics on prostaglandin activity in cisternal C.S.F. of unanaesthetized cats. J. Physiol. (Lond.)234, 279–303 (1973)

    Google Scholar 

  9. Feldberg, W., Saxena, P. N.: Prostaglandins, endotoxin, and Lipid A on body temperature in rats J. Physiol. (Lond.)249, 601–615 (1975)

    Google Scholar 

  10. Gessa, G. L., Krishna, G., Forn, J., Tagliamonte, A., Brodie, B. B.: Behavioral and vegetative effects produced by dibutyryl cyclic AMP injected into different areas of the brain. In: Role of cyclic AMP in cell function. Advanc. Biochem. Psychopharmacol., Vol. III, P. Greengard and E. Costa, eds., pp. 371–381. New York: Raven Press 1970

    Google Scholar 

  11. Gilman, A. G.: A protein binding assay for adenosine 3′:5′-cyclic monophosphate. Proc. nat. Acad. Sci. (Wash.)67, 305–312 (1970)

    Google Scholar 

  12. Gilman, A. G., Nirenberg, M.: Regulation of adenosine 3′,5′-cyclic monophosphate metabolism in cultured neuroblastoma cells. Nature (Lond.)234, 356–358 (1971)

    Google Scholar 

  13. Hasselblatt, A., Sproull, D. H.: Hyperglycaemia induced by drugs. J. Physiol. (Lond.)157, 124–136 (1961)

    Google Scholar 

  14. Kuehl, F. A., Jr., Humes, J. L., Tarnoff, J., Cirrillo, V. J., Ham, E. A.: Prostaglandin receptor site: Evidence for an essential role in the action of luteinizing hormone. Science169, 883–886 (1970)

    Google Scholar 

  15. Lüderitz, O., Galanos, Ch., Lehmann, V., Rietschel, E. Th.: Recent findings on the chemical structure and biological activity of bacterial lipopolysaccharides. J. Hyg. Epidem. (Praha)18, 381–390 (1970)

    Google Scholar 

  16. Milton, A. S., Dascombe, M. J.: The effect of caffein on pyrogen fever and on the antipyretic action of aspirin. In: The pharmacology of thermoregulation, E. Schönbaum and P. Lomax, eds., pp. 449–500. Basel: Karger 1973

    Google Scholar 

  17. Moore, D. M., Murphy, P. A., Chesney, P. J., Wood, W. B.: Synthesis of endogenous pyrogen by rabbit leucocytes. J. exp. Med.137, 1263–1274 (1973)

    Google Scholar 

  18. Philipp-Dormston, W. K.: Prostaglandine im Zentralnervensystem des Kaninchens. Hoppe-Seylers Z. physiol. Chem.356, 263 (1975)

    Google Scholar 

  19. Philipp-Dormston, W. K.: Cyclic AMP synthesis in rabbit brain during experimental fever. Abstract No. 1330 of the 10th meeting of the Federation of the European Biochemical Societies, Paris 1975

  20. Philipp-Dormston, W. K., Siegert, R.: Identification of prostaglandin E by radioimmunoassay in cerebrospinal fluid during endotoxin fever. Naturwissenschaften61, 134–135 (1974)

    Google Scholar 

  21. Philipp-Dormston, W. K., Siegert, R.: Prostaglandins of the E and F series in rabbit cerebrospinal fluid during fever induced by Newcastle disease virus, E. coli-endotoxin, or endogenous pyrogen. Med. Microbiol. Immunol.159, 279–284 (1974)

    Google Scholar 

  22. Philipp-Dormston, W. K., Siegert, R.: Plasma prostaglandins of the E. and F. series in rabbits during fever induced by New-castle disease virus, E. coli-endotoxin, or endogenous pyrogen. Z. Naturforsch.29c, 773–776 (1974)

    Google Scholar 

  23. Philipp-Dormston, W. K., Siegert, R.: Adenosine 3′,5′-cyclic monophosphate in rabbit cerebrospinal fluid during fever induced by E. coli-endotoxin. Med. Microbiol. Immunol.161, 11–13 (1975)

    Google Scholar 

  24. Philipp-Dormston, W. K., Siegert, R.: Fever produced in rabbits by N6, O2-dibutyryl adenosine 3′,5′-cyclic monophosphate. Experientia (Basel)31, 471–472 (1975)

    Google Scholar 

  25. Samuelsson, B.: Round table discussion on analytical methods. Advanc. Biosci.9, 121–123 (1973)

    Google Scholar 

  26. Sato, S., Szabo, M., Kowalski, K., Burke, G.: Role of prostaglandin in thyrotropin action on thyroid. Endocrinology90, 343–356 (1972)

    Google Scholar 

  27. Sebens, J. B., Korf, J.: Cyclic AMP in cerebrospinal fluid: Accumulation following probenecid and biogenic amines. Exp. Neurol.46, 333–344 (1975)

    Google Scholar 

  28. Siegert, R., Braune, P.: The pyrogens of myxoviruses. I. Induction of hyperthermia and its tolerance. Virology24, 209–217 (1964)

    Google Scholar 

  29. Siegert, R., Shu, H. L., Pollmann, W., Menzel, H.: Untersuchungen über Viruspyrogene. 1. Mitt.: Versuche zur Abtrennung des pyrogenen Prinzips von Myxoviren. Z. Naturforsch.22b, 155–158 (1967)

    Google Scholar 

  30. Sutherland, E. W., Øye, I., Butcher, R. W.: The action of epinephrine and the role of the adenyl cyclase system in hormone action. Recent Progr. Hormone Res.21, 623–646 (1965)

    Google Scholar 

  31. Varagić, V. M., Beleslin, D. B.: The effect of cyclic N-2-odibutyryl adenosine-3′,5′-monophosphate, adenosine triphosphate and butyrate on the body temperature of conscious cats. Brain Res.57, 252–254 (1973)

    Google Scholar 

  32. Westphal, O., Lüderitz, O., Bister, F.: Über die Extraktion von Bakterien mit Phenol/Wasser. Z. Naturforsch.7b, 148–155 (1952)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hygiene-Institut der Universität Marburg, Pilgrimstein 2, D-3550, Marburg/Lahn, Federal Republic of Germany

    Wolfgang K. Philipp-Dormston

Authors
  1. Wolfgang K. Philipp-Dormston
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Philipp-Dormston, W.K. Evidence for the involvement of adenosine 3′,5′-cyclic monophosphate in fever genesis. Pflugers Arch. 362, 223–227 (1976). https://doi.org/10.1007/BF00581174

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00581174

Key words

Search

Navigation