Abstract
Fevers induced by intravenous injection of endogenous pyrogen (EP) and intraventricular prostaglandin E2 (PGE2) were significantly prolonged when protein synthesis inhibitor, anisomycin was administrated intraventricularlly 30 min before or 1 hr after injection of EP or PGE2. The present results show that protein synthesis in the central nervous system is involved in the development of antipyresis.
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Morimoto, A., Nakamori, T., Watanabe, T. et al. Suppression of antipyretic response in rabbits by intraventricular protein synthesis inhibitor, anisomycin. Pflugers Arch. 408, 414–416 (1987). https://doi.org/10.1007/BF00581138
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DOI: https://doi.org/10.1007/BF00581138