Chemistry of Natural Compounds

, Volume 9, Issue 1, pp 82–87 | Cite as

Use of electron-spin-resonance spectroscopy for studying the conformational states of peptides gramicidin S

  • V. T. Ivanov
  • A. I. Miroshnikov
  • L. G. Snezhkova
  • Yu. A. Ovchinnikov
  • A. V. Kulikov
  • G. I. Likhtenshtein
Article
  • 15 Downloads

Summary

1. A new method has been proposed for studying the conformational states of peptides in solutions which is based on a consideration of the ESR spectra of their spin-labeled derivatives.

2. The synthesis of derivatives of gramicidin S containing one and two iminoxyl radicals in the2Orn and7Orn side chains has been effected.

3. On the basis of an analysis of the ESR spectra of the compounds obtained at −196°C and 30–62°C, conformations of the side chains of modified ornithine residues in chloroform and ethanol have been proposed.

Keywords

Conformational State Gramicidin Succinimide Radical Fragment OCOC 

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Copyright information

© Consultants Bureau, a division of Plenum Publishing Corporation 1975

Authors and Affiliations

  • V. T. Ivanov
  • A. I. Miroshnikov
  • L. G. Snezhkova
  • Yu. A. Ovchinnikov
  • A. V. Kulikov
  • G. I. Likhtenshtein

There are no affiliations available

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