Abstract
A new externally adjustable constrictor device for renal artery stenosis in the dog is described. The constrictor combines hydraulic and mechanical characteristics, and is connected to the exterior of the animal by a thin catheter. Applying hydraulic pressure via the catheter causes the plunger in the device to compress the renal artery to any desired degree of stenosis. A mechanical catch prevents backward movement of the plunger, thus ensuring a stable, irreversible renal artery constriction. This constrictor was implanted in 13 dogs, together with an electromagnetic blood flow sensor around a renal artery. In twelve dogs the constriction procedure was performed 3–12 weeks after implantation, and in all 12 cases the intended degree of stenosis [defined as percentage renal blood flow reduction (RBF)] was achieved within a range of 10%. In 5 dogs the long-term stability of the stenosis was studied and the RBF reduction appeared to be stable up to at least 6 weeks after constriction. In conclusion, the presented constrictor device is easily externally adjustable, and allows induction of a stable renal artery stenosis of various degrees in the conscious dog.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Anderson WP, Korner PI, Johnston CI (1979) Acute angiotensin II-mediated restoration of distal renal artery pressure in renal artery stenosis and its relationship to the development of sustained one-kidney hypertension in conscious dogs. Hypertension 1:292–298
Beran AV, Strauss J, Brown CT, Katurich N (1968) A simple arterial occluder. J Appl Physiol 24:838–839
Eckstein RW, Driscol TE (1963) Technique for temporary or chronic vascular occlusion or narrowing in intact animals. Proc Soc Exp Biol Med 112:318–319
Ferrario CM, Blumle C, Nadzam GR, McCubbin JW (1971) An externally adjustable renal artery clamp. J Appl Physiol 31:635–637
Goldblatt H (1944) Hypertension: experimental, by constriction of main renal arteries; method. In: Glasser O (ed) Medical physics. Year Book, Chicago, Ill, pp 622–625
Gutmann FD, Tagawa H, Haber E, Barger AC (1973) Renal arterial pressure, renin secretion, and blood pressure control in trained dogs. Am J Physiol 224:66–72
Jacobsen E, Swann KG (1966) Hydraulic occluder for chronic electromagnetiuc blood flow determination. J Appl Physiol 21:1400–1402
Jonker GJ, de Zeeuw D, Huisman RM, van der Hem GK (1985) Pharmacological zero for electromagnetic renal blood flow measurement. Pflügers Arch 403:220–221
Khouri EM, Gregg DE (1967) An inflatable cuff for zero flow determination in blood flow studies. J Appl Physiol 23:395–397
Nelson PJ (1967) Vascular pneumatic constrictor for in vivo calibration of electromagnetic flowmeters. J Appl Physiol 22:818–819
Rocchini AP, Barger AC (1979) Renovascular hypertension in sodium-depleted dogs: role of renin and carotid sinus reflex. Am J Physiol 236:H101–107
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jonker, GJ., de Zeeuw, D., Huisman, R.M. et al. A new constrictor device for external induction of a long-term stable and irreversible renal artery stenosis in the dog. Pflugers Arch. 411, 688–691 (1988). https://doi.org/10.1007/BF00580867
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00580867