Acta Diabetologica

, Volume 31, Issue 1, pp 1–5 | Cite as

Clinical reliability of multi-drug intracavernous vasoactive pharmacotherapy for diabetic impotence

  • F. Montorsi
  • G. Guazzoni
  • F. Bergamaschi
  • M. Zucconi
  • P. Rigatti
  • G. Pizzini
  • A. Miani
  • G. Pozza


The aim of this study was to assess the effectiveness and safety of intracavernous injections of a fourdrug vasoactive mixture in diabetic patients with organic impotence. A group of 60 diabetic patients with either pure neurogenic, pure vasculogenic or mixed neurovasculogenic impotence were treated with intracavernous injections of a combination of 12.1 mg/ml papaverine hydrochloride, 1.01 mg/ml phentolamine mesylate, 10.1 μg/ml prostaglandin E1 and 0.15 mg/ml atropine sulphate (‘full-dose’ mixture). A mixture of the same drugs but at one-third concentrations (‘reduced-dose” mixture) was also used. The mean (±SEM) volumes of the full-dose and reduced-dose mixtures used were 0.21±0.03 ml and 0.31±0.02 ml, respectively. All the patients were able to sustain a rigid erection at the end of the titration phase of the study. At a mean follow-up of 18 months, 48 patients (80%) were successfully using the mixture, 6 patients (10%) were using the mixture at a dose lower than the initial dose and 6 patients (10%) had dropped out from the injection therapy. No major complications were seen. The association of multiple vasoactive drugs which use different mechanisms of action, thus exerting a pharmacological synergism, is an effective and safe procedure in intracavernous pharmacotherapy for diabetic patients with organic impotence.

Key words

Diabetic impotence Papaverine Phentolamine Alprostadil Atropine 


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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • F. Montorsi
    • 1
    • 5
  • G. Guazzoni
    • 2
  • F. Bergamaschi
    • 2
  • M. Zucconi
    • 3
    • 5
  • P. Rigatti
    • 2
  • G. Pizzini
    • 1
    • 5
  • A. Miani
    • 1
    • 5
  • G. Pozza
    • 4
    • 5
  1. 1.Institute of Human AnatomyMilanItaly
  2. 2.Department of UrologyScientific Institute H. San RaffaeleMilanItaly
  3. 3.Department of NeurologyScientific Institute H. San RaffaeleMilanItaly
  4. 4.Department of Internal MedicineScientific Institute H. San RaffaeleMilanItaly
  5. 5.University of Milan School of MedicineMilanItaly

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