Pflügers Archiv

, Volume 407, Issue 2, pp 204–210 | Cite as

Excretion-retention data of steady state gas exchange in tidal breathing

I. Dependency on the blood-gas partition coefficient
  • Aart Zwart
  • Sybrand C. M. Luijendijk
  • Wouter R. de Vries
Heart, Circulation, Respiration and Blood; Environmental and Exercise Physiology


The aim of this study is to investigate the steady state gas transfer properties of the lungs. These properties can be derived from excretion-retention (E-R) data of inert tracer gases that are infused intravenously.E=PĒ/Pv andR=Pa/Pv, wherePĒ,Pa andPv represent the partial pressures of the tracer gases in mixed expired gas, arterial blood and mixed venous blood, respectively. In this paper, special attention is paid to the effects of tidal breathing onE-R data sets of tracer gases with different blood-gas partition coefficients. To that end,E-R data sets have been simulated with a lung model that takes into account tidal breathing, the morphometric geometry of the airways, diffusion limited gas mixing and gas dissolved in superficial lung tissue. The simulatedE-R data sets are compared withE-R data sets obtained from anaesthetized dogs. Both the simulatedE-R data sets and most of the in vivo determinedE-R data sets are incompatible with a model description of pulmonary gas transfer with parallel placed compartments with different ventilation-perfusion ratios. Concerning the simulatedE-R data sets, this incompatibility is due to the large buffering capacity of lung tissue for highly soluble gases in combination with the within-breath partial pressure oscillations in the airways.

Key words

Excretion Retention Constant rate process Tidal breathing Buffering of lung tissue RecoveredV/Q distributions 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Aart Zwart
    • 1
  • Sybrand C. M. Luijendijk
    • 2
  • Wouter R. de Vries
    • 2
  1. 1.Toxicology and Nutrition InstituteTNO-CIVOZeist
  2. 2.Department of Medical PhysiologyState University UtrechtUtrechtThe Netherlands

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