Pflügers Archiv

, Volume 397, Issue 4, pp 284–289 | Cite as

Effects of heart rate and perfusion pressure on segmental coronary resistances and collateral perfusion

  • Gerd Heusch
  • Nobuo Yoshimoto
Heart, Circulation, Respiration and Blood; Environmental and Exercise Physiology


This study examined the responsiveness of coronary arteries and microvessels to changes in heart rate and perfusion pressure. Our purpose was to determine quantitatively the sensitivity of segmental coronary resistances upon these hemodynamic interventions and to study their significance for collateral circulation.

Collateral perfusion pressurePPC was measured as peripheral coronary pressure of an occluded coronary artery after embolisation of its terminal vascular bed with 25 μm microspheres in 7 open chest dogs. With measurement ofPPC it was then possible to determine the segmental coronary resistances of the coronary arteries and the microvasculature.

Atrial pacing up to 220 min−1 decreasedPPC from 54±6 to 45±6 mm Hg (P<0.01); after maximum dilation with carbochromene (3 mg/kg i.v.) and dipyridamole (0.2 mg/kg i.v.) pacing increasedPPC from 34±8 to 39±8 mm Hg (P<0.01).

Elevating coronary perfusion pressure from 53±4 to 107±4 mm Hg induced an increase in the resistance of arteries up to the origin of collaterals by 19% (P<0.01) and in the resistance of the distal microvessels by 34% (P<0.01); after maximum dilation elevating perfusion pressure decreased proximal resistance by 32% (P<0.01) and distal resistance by 60% (P<0.01).

These results demonstrate that collateral circulation depends on collateral perfusion pressure in the donor coronary artery which is subject to metabolic regulation, as well as on the pressure at the orifice of collaterals to the ischemic vasculature which is passively subject to mechanical influences of diastolic duration and perfusion pressure.

Key words

Segmental coronary resistances Coronary collateral circulation Heart rate Coronary perfusion pressure 


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  1. Arnold G, Kosche F, Miessner, E, Neitzert A, Lochner W (1968) The importance of the perfusion pressure in the coronary arteries for the contractility and the oxygen consumption in the heart. Pflügers Arch 299:339–356Google Scholar
  2. Bache RJ, Cobb FR (1977) Effect of maximal coronary vasodilation on transmural myocardial perfusion during tachycardia in the awake dog. Circ Res 41:648–653Google Scholar
  3. Bache RJ, Schwartz JS (1982) Effect of perfusion pressure distal to a coronary stenosis on transmural myocardial blood flow. Circulation 65:928–935Google Scholar
  4. Becker L (1976) Effect of tachycardia on left ventricular blood flow distribution during coronary occlusion. Am J Physiol 230:1072–1077Google Scholar
  5. Bellamy RF (1978) Diastolic coronary artery pressure-flow relations in the dog. Circ Res 43:92–101Google Scholar
  6. Bloor CM, White FC (1972) Functional development of the coronary collateral circulation during coronary artery occlusion in the conscious dog. Am J Pathol 67:483–500Google Scholar
  7. Bloor CM (1974) Functional significance of the coronary collateral circulation. Am J Pathol 76:562–586Google Scholar
  8. Boatwright RB, Downey HF, Bashour FA, Crystal GJ (1980) Transmural variation in autoregulation of coronary blood flow in hyperperfused canine myocardium. Circ Res 47:599–609Google Scholar
  9. Cibulski AA, Lehan PH, Hellems HK (1973) Myocardial collateral flow measurements in mongrel dogs. Am J Physiol 225:559–565Google Scholar
  10. Domenech RJ, Goisch J (1976) Effect of heart rate on regional coronary blood flow. Cardovasc Res 10:224–231Google Scholar
  11. Downey HF, Bashour FA, Stephens AJ, Kechejian SJ, Underwood RH (1974) Transmural gradient of retrograde collateral blood flow in acutely ischemic canine myocardium. Circ Res 35:365–371Google Scholar
  12. Downey JM, Kirk ES (1975) Inhibition of coronary blood flow by a vascular waterfall mechanism. Circ Res 36:753–760Google Scholar
  13. Downey JM (1976) Myocardial contractile force as a function of coronary blood flow. Am J Physiol 230:1–6Google Scholar
  14. Downey JM, Chagrasulis RW (1976) The effect of cardiac contraction on collateral resistance in the canine heart. Circ Res 39:797–800Google Scholar
  15. Driscol TE, Moir TW, Eckstein RW (1964) Vascular effects of changes in perfusion pressure in the nonischemic and ischemic heart. Circ Res 15 (Suppl. I): 94–102Google Scholar
  16. Elliot EC, Khouri EM, Snow JA, Gregg DE (1974) Direct measurement of coronary collateral blood flow in conscious dogs by an electromagnetic flowmeter. Circ Res 34:374–383Google Scholar
  17. Ertl G, Fuchs M (1980) Alpha-adrenergic vasoconstriction in arterial and arteriolar sections of the canine coronary circulation. Basic Res Cardiol 75:600–614Google Scholar
  18. Fam WM, McGregor M (1968) Effect of nitroglycerin and dipyridamole on regional coronary resistance. Circ Res 22:649–659Google Scholar
  19. Fam WM, McGregor M (1969) Pressure-flow relationships in the coronary circulation. Circ Res 25:293–301Google Scholar
  20. Fedor JM, Rembert JC, McIntosh DM, Greenfield JC (1980) Effects of exercise- and pacing-induced tachycardia on coronary collateral flow in the awake dog. Circ Res 25:214–220Google Scholar
  21. Flameng W, Wüsten B, Winkler B, Pasyk S, Schaper W (1975) Influence of perfusion pressure and heart rate on local myocardial flow in the collateralized heart with chronic coronary occlusion. Am Heart J 89:51–59Google Scholar
  22. Grayson J, Davidson JW, Fitzgerald-Finch A, Scott C (1974) The functional morphology of the coronary microcirculation in the dog. Microvasc Res 8:20–43Google Scholar
  23. Kelley KO, Feigl EO (1978) Segmental α-receptor mediated vasoconstriction in the canine coronary circulation. Circ Res 43:908–917Google Scholar
  24. Laurent D, Bolene-Williams C, Williams FL, Katz LN (1956) Effects of heart rate on coronary flow and cardiac oxygen consumption. Am J Physiol 185:355–364Google Scholar
  25. Mosher P, Ross J, McFate PA, Shaw RF (1964) Control of coronary blood flow by an autoregulatory mechanism. Circ Res 14:250–259Google Scholar
  26. Munch DF, Downey JM (1980) Prediction of regional myocardial blood flow in dogs. Am J Physiol 239:H308-H315Google Scholar
  27. Neill WA, Oxendine J, Phelps N, Anderson RP (1975) Subendocardial ischemia provoked by tachycardia in conscious dogs with coronary stenosis. Am J Cardiol 35:30–36Google Scholar
  28. Raff WK, Kosche F, Lochner W (1972) Extravascular coronary resistance and its relation to microcirculation. Am J Cardiol 29:598–603Google Scholar
  29. Redwood DR, Smith ER, Epstein SE (1972) Coronary artery occlusion in the conscious dog: effects of alterations in heart rate and arterial pressure on the degree of myocardial ischemia. Circulation 46:323–332Google Scholar
  30. Schaper W (1971) The collateral circulation of the heart. Amsterdam, North-Holland Publishing CompanyGoogle Scholar
  31. Scheel KW, Brody DA, Ingram LA, Keller F (1976) Effects of chronic anemia on the coronary and coronary collateral vasculature in dogs. Circ Res 38:553–559Google Scholar
  32. Schulz FW, Raff WK, Meyer U, Lochner W (1973) Messung der Kollateraldurchblutung am Hundeherzen mit Hilfe der selektiven Embolisierung eines Coronargefäßes. Pflügers Arch 341:243–256Google Scholar
  33. Schwartz JS, Carlyle PF, Cohn JN (1979) Effect of dilation of the distal coronary bed on flow and resistance in severely stenotic coronary arteries in the dog. Am J Cardiol 43:219–224Google Scholar
  34. Tillmanns H, Steinhausen M, Leinberger H, Thederan H, Kübler W (1981) Pressure measurements in the terminal vascular bed of the epimyocardium of rats and cats. Circ Res 49:1202–1211Google Scholar
  35. Wichmann J, Lōser R, Diemer HP, Lochner W (1978) Pharmacological alterations of coronary collateral circulation: implication to the steal-phenomenon. Pflügers Arch 373:219–224Google Scholar
  36. Wiecken DEL, Paolini HJ, Eikens E (1971) Evidence for intravenous dipyridamole (persantin) producing a “coronary steal” effect in the ischemic myocardium. Aust N Z J Med 1:8–14Google Scholar
  37. Winbury MW, Howe BB, Hefner MA (1969) Effect of nitrates and other coronary dilators on large and small coronary vessels: an hypothesis for the mechanism of action of nitrates. J Pharmacol Exp Therap 168:70–95Google Scholar
  38. Wyatt D, Lee J, Downey JM (1982) Determination of coronary collateral flow by a load line analysis. Circ Res 50:663–670Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Gerd Heusch
    • 1
  • Nobuo Yoshimoto
    • 1
  1. 1.Physiologisches Institut I der Universität DüsseldorfDüsseldorfGermany

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